Glucocorticoid therapy in acute liver failure: Survival outcomes, predictors, and a response prediction model

Table 2 Univariate and multivariate analyses of the efficacy of corticosteroid therapy in patients with acute liver failure

Characteristic	Univariate analysis		Multivariate analysis
	OR (95%CI)	P value	OR (95%CI)	P value
Age	0.84 (0.54-1.29)	0.42	-	-
Gender	1.24 (0.52-2.95)	0.63	-	-
WBC	0.88 (0.57-1.35)	0.55	-	-
NEUT	0.82 (0.53-1.27)	0.37	-	-
HGB	1.20 (0.78-1.85)	0.41	-	-
NLR	0.63 (0.39-1.01)	0.05	-	-
PLT	1.09 (0.70-1.69)	0.69	-	-
ALT	0.68 (0.43-1.08)	0.10	-	-
AST	0.51 (0.24-1.08)	0.08	-	-
AST/ALT	0.96 (0.62-1.48)	0.85	-	-
TBIL	0.86 (0.56-1.33)	0.50	-	-
UREA	0.77 (0.42-1.43)	0.42	-	-
Cr	0.88 (0.57-1.36)	0.58	-	-
INR	0.38 (0.16-0.92)	0.03	1.28 (0.60-2.70)	0.53
PT	0.39 (0.20-0.77)	0.01	0.83 (0.39-1.77)	0.63
PTA	3.24 (1.77-5.94)	< 0.001	4.21 (1.09-16.34)	0.04
ΔPTA	4.96 (2.39-10.33)	< 0.001	7.78 (2.79-21.68)	< 0.001
Blood ammonia	0.46 (0.27-0.79)	0.01	0.42 (0.19-0.96)	0.04

WBC: White blood cell; NEUT: Neutrophil; HGB: Haemoglobin; NLR: Neutrophil-lymphocyte ratio; PLT: Platelet; ALT: Alanine transferase; AST: Aspartate transferase; TBIL: Total bilirubin; UREA: Blood urea; Cr: Creatinine; INR: International normalized ratio; PT: Prothrombin Time; PTA: Prothrombin activity; ΔPTA: Prothrombin activity on day 3-baseline prothrombin activity; NH3: Blood ammonia; OR: Odds ratio.