Novel nomogram for differential diagnosis of UGT1A1 gene mutation-associated unconjugated hyperbilirubinemia with hemolytic diseases

Table 3 Univariate and multivariable logistic regression analysis to identify factor for differential diagnosis (backward stepwise regression)

Variables	Univariate analysis					Multivariate analysis
	β	SE	Z	P value	OR (95%CI)	β	SE	Z	P value	OR (95%CI)
Splenomegaly
No					1.00 (reference)
Yes	4.28	0.49	8.82	< 0.001	72.14 (27.88-186.68)
Peripheral blood smear
Normal					1.00 (reference)					1.00 (reference)
Abnormal	4.66	0.65	7.14	< 0.001	105.61 (29.37-379.76)	4.12	1.74	2.37	0.018	61.73 (2.05-1854.84)
RDWSD
< 45.55 fL					1.00 (reference)					1.00 (reference)
≥ 45.55 fL	5.49	0.6	9.11	< 0.001	241.44 (74.19-785.72)	3.43	1.24	2.76	0.006	30.72 (2.71-348.77)
RET percentage
< 2.1%					1.00 (reference)					1.00 (reference)
≥ 2.1%	5.72	0.77	7.42	< 0.001	304.50 (67.25-1378.84)	4.43	1.21	3.65	< 0.001	84.27 (7.82-908.54)
HCT
< 40.15%					1.00 (reference)					1.00 (reference)
≥ 40.15%	-3.41	0.47	-7.25	< 0.001	0.03 (0.01-0.08)	-2.16	1.07	-2.02	0.043	0.11 (0.01-0.94)
IBiL/TBiL ratio	10.2	1.67	6.09	< 0.001	26851.06 (1009.96-713868.82)	7.81	4.68	1.67	0.095	2457.55 (0.25-23737621.41)

OR: Odds ratio; CI: Confidence interval; RDWSD: Red cell distribution width-standard deviation; RET: Reticulocyte; HCT: Hematocrit; IBiL: Indirect bilirubin; TBiL: Total bilirubin.