Metabolic dysfunction-associated steatotic liver disease mediates the relationship between Helicobacter pylori infection and colorectal adenoma risk

doi:10.4254/wjh.v18.i4.115475

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World Journal of Hepatology

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1948-5182

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World J Hepatol. Apr 27, 2026; 18(4): 115475
Published online Apr 27, 2026. doi: 10.4254/wjh.v18.i4.115475

Table 5 Mediation effect of metabolic dysfunction-associated steatotic liver disease in the influence of Helicobacter pylori on colorectal adenoma occurrence

	OR (95%CI)	P value¹
Total effect	0.0563 (0.0387-0.0763)	< 0.0001
Direct effect	0.0554 (0.0037-0.0753)	< 0.0001
Mediation effect	0.0009 (0.0002-0.0027)	0.0180
Mediation effect percentage	0.0168 (0.0037-0.0510)	0.0180

¹Adjusting for confounding factors 1: Age and sex.

MASLD: Metabolic dysfunction-associated steatotic liver disease; OR: Odds ratio.

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Citation: Cai ZB, Su BB, Shi PY, Wang SS, Shi H, Chen QQ. Metabolic dysfunction-associated steatotic liver disease mediates the relationship between Helicobacter pylori infection and colorectal adenoma risk. World J Hepatol 2026; 18(4): 115475
URL: https://www.wjgnet.com/1948-5182/full/v18/i4/115475.htm
DOI: https://dx.doi.org/10.4254/wjh.v18.i4.115475

Cai ZB, Su BB, Shi PY, Wang SS, Shi H, Chen QQ. Metabolic dysfunction-associated steatotic liver disease mediates the relationship between Helicobacter pylori infection and colorectal adenoma risk. World J Hepatol 2026; 18(4): 115475 [DOI: 10.4254/wjh.v18.i4.115475]

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