Metabolic dysfunction-associated steatotic liver disease mediates the relationship between Helicobacter pylori infection and colorectal adenoma risk

Table 4 Multivariate logistic regression model for colorectal adenoma and the interaction between Helicobacter pylori and metabolic dysfunction-associated steatotic liver disease

	Adjusting for confounding factors 11		Adjusting for confounding factors 22
	OR (95%CI)	P value	OR (95%CI)	P value
H. pylori (-) MASLD (-)	1.0		1.0
H. pylori (+) MASLD (-)	1.24 (1.11-1.39)	0.0002	1.28 (1.12-1.45)	0.0002
H. pylori (-) MASLD (+)	1.28 (1.11-1.48)	0.0006	1.18 (1.02-1.40)	0.0430
H. pylori (+) MASLD (+)	1.68 (1.47-1.91)	< 0.0001	1.68 (1.45-1.93)	< 0.0001
Interaction between H. pylori infection and MASLD		0.2780		0.1836

¹Adjusting for confounding factors 1: Age and sex.

²Adjusting for confounding factors 2: Age, sex, white blood cell count, hemoglobin, folic acid, homocysteine, total cholesterol, creatinine, 25-hydroxyvitamin D3, smoking history, and drinking history.

H. pylori: Helicobacter pylori; MASLD: Metabolic dysfunction-associated steatotic liver disease; OR: Odds ratio.