Metabolic dysfunction-associated steatotic liver disease mediates the relationship between Helicobacter pylori infection and colorectal adenoma risk

doi:10.4254/wjh.v18.i4.115475

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Hepatol. Apr 27, 2026; 18(4): 115475
Published online Apr 27, 2026. doi: 10.4254/wjh.v18.i4.115475

Table 2 Association between Helicobacter pylori infection and adenoma (multivariate logistic regression model)

Helicobacter pylori infection test	Adjusting for confounding factors 1¹		Adjusting for confounding factors 2²
Helicobacter pylori infection test	OR (95%CI)	P value	OR (95%CI)	P value
-	1.0		1.0
+	1.3 (1.2-1.5)	< 0.001	1.3 (1.2-1.4)	< 0.001

¹Adjusting for confounding factors 1: Age, sex and body mass index.

²Adjusting for confounding factors 2: Age, sex, body mass index, systolic blood pressure, white blood cell count, hemoglobin, C-reactive protein, folic acid, homocysteine, total cholesterol, fasting blood glucose, creatinine, 25-hydroxyvitamin D3, smoking history, and drinking history.

OR: Odds ratio.

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Citation: Cai ZB, Su BB, Shi PY, Wang SS, Shi H, Chen QQ. Metabolic dysfunction-associated steatotic liver disease mediates the relationship between Helicobacter pylori infection and colorectal adenoma risk. World J Hepatol 2026; 18(4): 115475
URL: https://www.wjgnet.com/1948-5182/full/v18/i4/115475.htm
DOI: https://dx.doi.org/10.4254/wjh.v18.i4.115475

Cai ZB, Su BB, Shi PY, Wang SS, Shi H, Chen QQ. Metabolic dysfunction-associated steatotic liver disease mediates the relationship between Helicobacter pylori infection and colorectal adenoma risk. World J Hepatol 2026; 18(4): 115475 [DOI: 10.4254/wjh.v18.i4.115475]

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