Integrated transcriptomics and metabolomics reveal neutrophil extracellular trap associated with interferon treatment for chronic hepatitis B

doi:10.4254/wjh.v18.i4.114804

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Hepatol. Apr 27, 2026; 18(4): 114804
Published online Apr 27, 2026. doi: 10.4254/wjh.v18.i4.114804

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Figure 6 Metabolomics analysis after interferon treatment. A: Hierarchical clustering analysis of the top 20 differential metabolites in the B vs A group; red represents upregulation, and blue represents downregulation; B: Radar plot showing the top 10 differential metabolites in the B vs A group; C: Enrichment analysis of differential metabolites in the B vs A group; Kyoto Encyclopedia of Genes and Genomes classification chart; D: Enrichment analysis of differential metabolites in the B vs A group; bar chart of the top 15 enriched Kyoto Encyclopedia of Genes and Genomes pathways; E: Parts of the iPath analysis for metabolites in the B vs A group, including lipid metabolism and metabolism of other amino acids; F: Parts of the iPath analysis for metabolites in the B vs A group, including lipid metabolism; red lines indicate upregulated pathways.

Citation: Ye XY, He XZ, Hu ZT, Zheng FF, Huang XG, Xie XM, Chen FH, Ou HB, Qiu RX. Integrated transcriptomics and metabolomics reveal neutrophil extracellular trap associated with interferon treatment for chronic hepatitis B. World J Hepatol 2026; 18(4): 114804
URL: https://www.wjgnet.com/1948-5182/full/v18/i4/114804.htm
DOI: https://dx.doi.org/10.4254/wjh.v18.i4.114804

Ye XY, He XZ, Hu ZT, Zheng FF, Huang XG, Xie XM, Chen FH, Ou HB, Qiu RX. Integrated transcriptomics and metabolomics reveal neutrophil extracellular trap associated with interferon treatment for chronic hepatitis B. World J Hepatol 2026; 18(4): 114804 [DOI: 10.4254/wjh.v18.i4.114804]

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