Integrated transcriptomics and metabolomics reveal neutrophil extracellular trap associated with interferon treatment for chronic hepatitis B

Figure 1 Identification of differentially expressed genes after interferon treatment for chronic hepatitis B through transcriptomic analysis. A: Principal component analysis (PCA) of all differentially expressed genes (DEGs) across the four groups: Untreated (group A); 1-month interferon (IFN) treatment (group B); 3-month IFN treatment (group C); 6-month IFN treatment (group D); B: PCA comparing (B vs A); C: PCA comparing (B vs C); D: PCA comparing (C vs D); E: Venn diagram showing the overlap of all DEGs across the four groups; F: Volcano plots of DEGs in the comparisons (B vs A); G: Volcano plots of DEGs in the comparisons (C vs B); H: Volcano plots of DEGs in the comparisons (D vs C). PCA: Principal component analysis.