Time sensitive managements in hepato-gastroenterology

doi:10.4254/wjh.v18.i4.114793

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Hepatol. Apr 27, 2026; 18(4): 114793
Published online Apr 27, 2026. doi: 10.4254/wjh.v18.i4.114793

Table 4 Summary of the time-sensitive decisions in management of Clostridium difficile infection

Patient phenotype (stage of illness)	Recommended action	Time frame
Symptomatic (suspected)	Multi-step diagnostics + start empiric therapy (fidaxomicin or vancomycin)	Within 24 hours
Severe/fulminant	High-dose oral vancomycin + IV metronidazole; consider rectal vancomycin	Immediately
First recurrence	Switch to fidaxomicin	As early as possible after recurrence
≥ 2 recurrences	Add fecal microbiota transplantation promptly	As early as possible
Fulminant refractory to medical therapy	Surgical consultation (or ileostomy lavage)	Within hours/days of deterioration

Full Size Table

Citation: Said EM, Soliman HH, Gabal HMR, Emara MH, Fouad Y, Elzahaby A, Anees M, Zaky S, Sakr MA. Time sensitive managements in hepato-gastroenterology. World J Hepatol 2026; 18(4): 114793
URL: https://www.wjgnet.com/1948-5182/full/v18/i4/114793.htm
DOI: https://dx.doi.org/10.4254/wjh.v18.i4.114793

Said EM, Soliman HH, Gabal HMR, Emara MH, Fouad Y, Elzahaby A, Anees M, Zaky S, Sakr MA. Time sensitive managements in hepato-gastroenterology. World J Hepatol 2026; 18(4): 114793 [DOI: 10.4254/wjh.v18.i4.114793]

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