Overexpression and clinicopathological significance of cullin-2 in hepatocellular carcinoma progression

doi:10.4254/wjh.v18.i3.117134

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Hepatol. Mar 27, 2026; 18(3): 117134
Published online Mar 27, 2026. doi: 10.4254/wjh.v18.i3.117134

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Figure 10 Functional enrichment analysis of Cullin-2 in hepatocellular carcinoma. A: Hallmark pathway analysis reveals significant enrichment of E2F targets, G2M checkpoint, and MYC signaling in Cullin-2 (CUL2)-high tumors; B: Gene Ontology analysis shows association with DNA replication, sister chromatid segregation, and cell cycle progression; C: CUL2 is also enriched in pathways related to nuclear migration and cellular motility; D: Gene set enrichment analysis enrichment plots confirm coordinated upregulation of key proliferation and EMT pathways in CUL2-high samples.

Citation: Tang P, Nong QH, Xiong KH, Tang HH, Huang BB, Huang GL, Li Q, He SP, Chen G, Feng ZB, Li JD. Overexpression and clinicopathological significance of cullin-2 in hepatocellular carcinoma progression. World J Hepatol 2026; 18(3): 117134
URL: https://www.wjgnet.com/1948-5182/full/v18/i3/117134.htm
DOI: https://dx.doi.org/10.4254/wjh.v18.i3.117134

Tang P, Nong QH, Xiong KH, Tang HH, Huang BB, Huang GL, Li Q, He SP, Chen G, Feng ZB, Li JD. Overexpression and clinicopathological significance of cullin-2 in hepatocellular carcinoma progression. World J Hepatol 2026; 18(3): 117134 [DOI: 10.4254/wjh.v18.i3.117134]

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