Immunogenetic and molecular biomarkers in COVID-19 and hepatitis C virus infection: Evaluating the diagnostic potential of HLA (rs1131500), IGF-2, and I-FABP

Figure 5 Receiver operating characteristic curves of insulin-like growth factor 2, intestinal fatty-acid-binding protein, and interferon-gamma for evaluating the sensitivity and specificity of insulin-like growth factor 2, intestinal fatty-acid-binding protein, and interferon-gamma in diagnosing infection. The curves illustrate the diagnostic performance of each biomarker, with the area under the curve (AUC) values shown in the figure. Insulin-like growth factor 2 demonstrated excellent discrimination (AUC = 0.996), while I-FABP and interferon-gamma showed more modest performance (AUC = 0.736 and 0.684, respectively). The diagonal line represents the line of no discrimination (AUC = 0.5). Sensitivity and specificity are plotted across different thresholds. HCV: Hepatitis C virus; COVID-19: Coronavirus disease 2019; IFN: Interferon; IGF: Insulin-like growth factor; I-FABP: Intestinal fatty-acid-binding protein.