Effects of tenofovir amibufenamide and entecavir on estimated glomerular filtration rate in treatment-naïve patients with chronic hepatitis B

Table 4 Comparison of baseline and endpoint clinical data between tenofovir amibufenamide and entecavir groups in patients with chronic hepatitis B, n (%)/median (interquartile range)/mean ± SD

Variables	ETV (n = 96)			TMF (n = 48)
	Baseline	Endpoint	P value	Baseline	Endpoint	P value
DNA positive	96 (100.00)	25 (26.04)	< 0.001	48 (100.00)	15 (31.25)	< 0.001
HBsAg (log10IU/mL)	3.50 (3.07-4.00)	3.36 (2.97-3.67)	0.087	3.66 (3.07-4.37)	3.37 (3.02-3.89)	0.175
HBeAg positive	46 (47.92)	38 (39.58)	0.244	21 (43.75)	20 (41.67)	0.837
TBIL (μmol/L)	15.8 (12.1-22.9)	13.1 (10.1-17.3)	0.006	15.8 (11.9-23.7)	12.4 (9.5-16.3)	0.010
Alb (g/L)	45.6 (43.0-47.5)	45.44 ± 2.87	0.674	44.8 (42.4-45.9)	45.35 ± 2.51	0.050
ALT (U/L)	53.2 (29.0-87.8)	23.3 (16.8-32.5)	< 0.01	45.8 (29.2-74.8)	26.3 (17.7-42.5)	< 0.01
AST (U/L)	37.7 (28.2-65.8)	23.8 (19.3-30.6)	< 0.01	35.9 (24.1-57.1)	22.7 (19.1-32.3)	< 0.01
GGT (U/L)	27.0 (17.0-53.7)	21.0 (14.2-28.8)	0.013	31.2 (18.2-59.5)	23.3 (15.0-35.8)	0.027
ALP (U/L)	79.7 (65.7-95.7)	75.04 ± 20.90	0.107	86.4 (68.6-101.2)	82.28 ± 24.97	0.575
TG (mmol/L)	1.07 (0.80-1.62)	1.14 (0.87-1.45)	0.481	1.24 (0.86-1.75)	1.38 (0.90-1.91)	0.354
TC (mmol/L)	4.43 (3.88-4.86)	4.39 (3.86-4.91)	0.977	4.53 (4.05-4.76)	4.62 (4.32-4.91)	0.096
FBG (mmol/L)	5.00 (4.68-5.35)	4.98 (4.63-5.46)	0.979	5.00 (4.76-5.29)	5.10 (4.77-5.32)	0.866
SCr (μmol/L)	66.48 ± 14.14	71.17 ± 13.87	0.021	67.01 ± 11.12	67.76 ± 11.36	0.745
eGFR (mL/minute/1.73 m2)	111.83 ± 10.16	106.10 ± 12.27	< 0.001	112.50 ± 10.28	111.01 ± 10.53	0.485
BUN (mmol/L)	4.18 ± 1.00	4.41 ± 1.14	0.149	4.33 ± 1.11	4.64 ± 1.06	0.160
HGB (g/L)	148 (135-159)	147 (135-158)	0.947	147 (135-159)	148 (137-158)	0.840
PLT (× 109/L)	201 ± 60	198 ± 61	0.694	196 ± 55	198 ± 52	0.793
LSM (kPa)	7.2 (6.0-10.3)	6.8 (5.4-8.5)	0.150	7.0 (6.0-7.6)	6.8 (5.5-7.8)	0.322
Liver cirrhosis	10 (10.42)	12 (12.50)	0.650	5 (10.42)	4 (8.33)	0.726

HBsAg: Hepatitis B surface antigen; HBeAg: Hepatitis B e antigen; TBIL: Total bilirubin; Alb: Albumin; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; GGT: Gamma-glutamyl transferase; ALP: Alkaline phosphatase; TG: Triglyceride; TC: Total cholesterol; FBG: Fasting blood glucose; SCr: Serum creatinine; eGFR: Estimated glomerular filtration rate; BUN: Blood urea nitrogen; HGB: Hemoglobin; PLT: Platelet; LSM: Liver stiffness measurement; ETV: Entecavir; TMF: Tenofovir amibufenamide.