Fatigue and circadian rhythm in non-cirrhotic primary biliary cholangitis: An exploratory comparison with primary sclerosing cholangitis and healthy controls

Table 5 Multivariable analysis of Morningness-Eveningness Questionnaire Self-Assessment score, mean ± SD

Chronotype (MEQ-SA)		Value	Coefficient (univariable)	Coefficient (multivariable full)	Coefficient (multivariable)
Group	PBC	59.3 ± 6.7
	PSC	53.8 ± 8.7	-5.46 (-8.90 to -2.02), P = 0.002	-2.29 (-6.25 to 1.66), P = 0.253	-2.38 (-6.07 to 1.30), P = 0.203
	HC	58.2 ± 8.4	-1.05 (-3.84 to 1.74), P = 0.459	-0.76 (-3.51 to 1.99), P = 0.586	-0.52 (-3.20 to 2.16), P = 0.703
Sex	Female	58.3 ± 7.7
	Male	55.7 ± 9.1	-2.58 (-5.75 to 0.59), P = 0.110	0.21 (-3.19 to 3.61), P = 0.903
Age	20.0-85.0	57.8 ± 8.0	0.20 (0.11-0.28), P < 0.001	0.20 (0.07-0.32), P = 0.002	0.22 (0.11-0.33), P < 0.001
Working hours	0.0-12.0	57.8 ± 8.0	-0.00 (-0.36 to 0.36), P = 0.997	0.33 (-0.22 to 0.89), P = 0.238	0.43 (0.06-0.80), P = 0.024
Employment	Employed	57.9 ± 7.3
	Retired	59.1 ± 7.5	1.20 (-1.46 to 3.86), P = 0.375	-0.36 (-5.07 to 4.34), P = 0.879
	Unemployed	50.8 ± 11.4	-7.14 (-11.88 to -2.41), P = 0.003	-4.03 (-9.11 to 1.06), P = 0.120

MEQ-SA: Morningness-Eveningness Questionnaire Self-Assessment; PBC: Primary biliary cholangitis; PSC: Primary sclerosing cholangitis; HC: Healthy controls.