Fatigue and circadian rhythm in non-cirrhotic primary biliary cholangitis: An exploratory comparison with primary sclerosing cholangitis and healthy controls

Table 4 Multivariable analysis of fatigue phenotype, n (%)/mean ± SD

Dependent: Type of fatigue	Mental	Muscular	OR, 95%CI (univariable)	OR, 95%CI (multivariable full)	OR, 95%CI (multivariable)
Group
PBC	19 (27.9)	42 (50.0)
PSC	12 (17.6)	18 (21.4)	0.68 (0.27-1.70), P = 0.403	1.19 (0.39-3.81), P = 0.769	1.25 (0.44-3.71), P = 0.681
HC	37 (54.4)	24 (28.6)	0.29 (0.14-0.61), P = 0.001	0.29 (0.13-0.63), P = 0.002	0.30 (0.14-0.63), P = 0.002
Sex
Female	55 (80.9)	66 (78.6)
Male	13 (19.1)	18 (21.4)	1.15 (0.52-2.61), P = 0.725	1.17 (0.45-3.13), P = 0.753
Age	57.1 ± 15.2	61.7 ± 12.8	1.02 (1.00-1.05), P = 0.047	1.04 (1.00-1.08), P = 0.054	1.04 (1.01-1.07), P = 0.016
Working hours	4.8 ± 3.5	4.3 ± 3.7	0.96 (0.88-1.05), P = 0.425	0.98 (0.84-1.16), P = 0.812
Employment
Employed	42 (61.8)	43 (51.2)
Retired	20 (29.4)	35 (41.7)	1.71 (0.86-3.46), P = 0.130	0.86 (0.22-3.39), P = 0.821
Unemployed	6 (8.8)	6 (7.1)	0.98 (0.28-3.36), P = 0.970	0.84 (0.20-3.65), P = 0.808

PBC: Primary biliary cholangitis; PSC: Primary sclerosing cholangitis; HC: Healthy controls; OR: Odds ratio; CI: Confidence interval.