Fatigue and circadian rhythm in non-cirrhotic primary biliary cholangitis: An exploratory comparison with primary sclerosing cholangitis and healthy controls

doi:10.4254/wjh.v18.i2.114206

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Observational Study

World J Hepatol. Feb 27, 2026; 18(2): 114206
Published online Feb 27, 2026. doi: 10.4254/wjh.v18.i2.114206

Table 3 Core outcomes, median (interquartile range)

	Overall (n = 152)	PBC (n = 61)	PSC (n = 30)	HC (n = 61)	P value
Daytime sleepiness (ESS)	5.50 (3.75-8.00)	6.00 (3.00-9.00)	6.00 (4.00-9.00)	5.00 (3.00-8.00)	0.376
Global fatigue (FIS)	34.00 (16.00-65.50)	32.00 (16.00-100.00)	24.00 (6.50-61.25)	37.00 (21.00-56.00)	0.308
PBC-40 fatigue domain¹	22.00 (14.00-30.50)	18.00 (13.00-30.00)	25.00 (15.25-30.75)	N/A	0.131²
Chronotype (MEQ-SA)	58.00 (53.00-64.00)	60.00 (55.00-63.00)	54.50 (46.75-59.00)	58.00 (53.00-65.00)	0.018

¹Primary biliary cholangitis-40 applies only to cholestatic cohorts.

²Mann-Whitney test (primary biliary cholangitis vs primary sclerosing cholangitis).

ESS: Epworth Sleepiness Scale; FIS: Fatigue Impact Scale; PBC: Primary biliary cholangitis; MEQ-SA: Morningness-Eveningness Questionnaire Self-Assessment; PSC: Primary sclerosing cholangitis; HC: Healthy controls; N/A: Not applicable.

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Citation: Curto A, Tanturli M, Iamello RG, Rossi P, Mengozzi G, Dei L, Mello T, Innocenti T, Dragoni G, Galli A, Lynch EN. Fatigue and circadian rhythm in non-cirrhotic primary biliary cholangitis: An exploratory comparison with primary sclerosing cholangitis and healthy controls. World J Hepatol 2026; 18(2): 114206
URL: https://www.wjgnet.com/1948-5182/full/v18/i2/114206.htm
DOI: https://dx.doi.org/10.4254/wjh.v18.i2.114206

Curto A, Tanturli M, Iamello RG, Rossi P, Mengozzi G, Dei L, Mello T, Innocenti T, Dragoni G, Galli A, Lynch EN. Fatigue and circadian rhythm in non-cirrhotic primary biliary cholangitis: An exploratory comparison with primary sclerosing cholangitis and healthy controls. World J Hepatol 2026; 18(2): 114206 [PMID: 41809483 DOI: 10.4254/wjh.v18.i2.114206]

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