Fatigue and circadian rhythm in non-cirrhotic primary biliary cholangitis: An exploratory comparison with primary sclerosing cholangitis and healthy controls

doi:10.4254/wjh.v18.i2.114206

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Hepatol. Feb 27, 2026; 18(2): 114206
Published online Feb 27, 2026. doi: 10.4254/wjh.v18.i2.114206

Table 2 Biochemistry, median (interquartile range)

	Overall (n = 152)	PBC (n = 61)	PSC (n = 30)	HC (n = 61)	P value
eGFR, mL/minU/1.73 m²	90.00 (78.35-90.00)	82.00 (70.00-90.00)	90.00 (90.00-90.00)	N/A	< 0.001
Thyroid stimulating hormone, mIU/L	2.01 (1.13-2.74)	1.23 (1.11-2.04)	2.85 (2.50-3.00)	N/A	< 0.001
Haemoglobin, g/dL	13.30 (12.50-14.10)	13.10 (12.30-13.80)	13.80 (13.00-15.20)	N/A	0.007
Hematocrit, %	41.10 (38.92-42.98)	41.10 (39.10-42.50)	41.50 (38.10-45.00)	N/A	0.360
Platelets, 10⁹/L	258.00 (212.25-300.75)	256.00 (222.00-290.00)	267.00 (202.00-312.00)	N/A	0.772
Ig(immunoglobulin), mg/dL	189.00 (148.00-303.50)	206.00 (155.50-304.25)	156.00 (105.50-269.50)	N/A	0.083
Albumin, g/dL	4.08 (3.90-4.31)	4.00 (3.80-4.30)	4.10 (4.00-4.50)	N/A	0.110
INR	1.00 (1.00-1.00)	1.00 (1.00-1.00)	1.00 (1.00-1.00)	N/A	0.277
Total bilirubin, mg/dL	0.63 (0.50-0.80)	0.60 (0.50-0.71)	0.85 (0.52-1.22)	N/A	0.008
ALT, U/L	23.00 (17.00-39.00)	22.00 (17.00-36.00)	27.50 (19.00-48.75)	N/A	0.157
AST, U/L	27.00 (21.00-33.00)	25.00 (21.00-33.00)	29.00 (22.25-41.75)	N/A	0.179
ALP, U/L	105.00 (79.00-138.00)	105.00 (77.00-138.00)	104.50 (84.75-140.50)	N/A	0.482
GGT, U/L	65.00 (32.00-118.00)	54.00 (33.00-86.00)	75.50 (30.50-154.25)	N/A	0.167

eGFR: Estimated glomerular filtrate rate; INR: International normalized ratio; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; ALP: Alkaline phosphatase; GGT: Gamma- glutamyl transferase; PBC: Primary biliary cholangitis; PSC: Primary sclerosing cholangitis; HC: Healthy controls; N/A: Not applicable.

Full Size Table

Citation: Curto A, Tanturli M, Iamello RG, Rossi P, Mengozzi G, Dei L, Mello T, Innocenti T, Dragoni G, Galli A, Lynch EN. Fatigue and circadian rhythm in non-cirrhotic primary biliary cholangitis: An exploratory comparison with primary sclerosing cholangitis and healthy controls. World J Hepatol 2026; 18(2): 114206
URL: https://www.wjgnet.com/1948-5182/full/v18/i2/114206.htm
DOI: https://dx.doi.org/10.4254/wjh.v18.i2.114206

Curto A, Tanturli M, Iamello RG, Rossi P, Mengozzi G, Dei L, Mello T, Innocenti T, Dragoni G, Galli A, Lynch EN. Fatigue and circadian rhythm in non-cirrhotic primary biliary cholangitis: An exploratory comparison with primary sclerosing cholangitis and healthy controls. World J Hepatol 2026; 18(2): 114206 [PMID: 41809483 DOI: 10.4254/wjh.v18.i2.114206]

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