Fatigue and circadian rhythm in non-cirrhotic primary biliary cholangitis: An exploratory comparison with primary sclerosing cholangitis and healthy controls

Table 1 Patients characteristics, median (interquartile range)/n (%)

	Overall (n = 152)	PBC (n = 61)	PSC (n = 30)	HC (n = 61)	P value
Age, years	61.50 (54.00-68.00)	63.00 (57.00-73.00)	50.50 (30.00-57.75)	62.00 (57.00-71.00)	< 0.001
BMI, kg/m2	23.67 (20.88-26.31)	24.58 (22.39-27.34)	22.56 (20.45-24.87)	23.18 (20.48-25.30)	0.012
Sleep duration hours	7.00 (6.00-7.12)	6.50 (5.50-7.00)	7.00 (6.50-7.50)	6.50 (6.00-7.00)	0.130
Number of awakenings	1.50 (1.50-1.50)	1.50 (1.50-1.50)	1.50 (0.00-2.25)	1.50 (1.50-1.50)	0.564
Working days/week	5.00 (0.00-5.00)	5.00 (0.00-5.00)	5.00 (5.00-6.00)	5.00 (0.00-5.00)	0.030
Working hours/day	5.50 (0.00-8.00)	5.00 (0.00-8.00)	7.00 (4.00-8.00)	4.00 (0.00-8.00)	0.040
Disease duration, years	10.00 (4.00-16.00)	10.50 (4.00-16.00)	10.00 (4.00-16.00)	N/A	0.914
Sex					< 0.001
Female	121 (79.6)	54 (88.5)	13 (43.3)	54 (88.5)
Male	31 (20.4)	7 (11.5)	17 (56.7)	7 (11.5)
Nocturnal light exposure					0.676
No	140 (92.1)	55 (90.2)	29 (96.7)	56 (91.8)
Yes	12 (7.9)	6 (9.8)	1 (3.3)	5 (8.2)
Employment					0.011
Employed	85 (55.9)	29 (47.5)	19 (63.3)	37 (60.7)
Retired	55 (36.2)	28 (45.9)	5 (16.7)	22 (36.1)
Unemployed	12 (7.9)	4 (6.6)	6 (20.0)	2 (3.3)
Anti-mitochondrial antibodies					1.000
Negative	11 (18.0)	11 (18.0)	N/A	N/A
Positive	50 (82.0)	50 (82.0)	N/A	N/A
Anti-Sp100					1.000
Negative	48 (78.7)	48 (78.7)	N/A	N/A
Positive	13 (21.3)	13 (21.3)	N/A	N/A
Fibroscan					0.362
F1	68 (75.6)	45 (73.8)	23 (79.3)	N/A
F2	16 (17.8)	13 (21.3)	3 (10.3)	N/A
F3	6 (6.7)	3 (4.9)	3 (10.3)	N/A
Drug					1.000
Fibrates	15 (24.6)	15 (24.6)	N/A	N/A
Obeticholic acid	8 (13.1)	8 (13.1)	N/A	N/A
Ursodeoxycholic acid	38 (62.3)	38 (62.3)	N/A	N/A

BMI: Body mass index; PBC: Primary biliary cholangitis; PSC: Primary sclerosing cholangitis; HC: Healthy controls; N/A: Not applicable.