Adipokine profiles reflect metabolic dysfunction but not fibrosis in patients with primary biliary cholangitis

Table 2 Baseline clinical and metabolic characteristics of patients with primary biliary cholangitis, n (%)/mean ± SD (range)

Characteristic	n = 81
Age (years)	64.28 ± 10.23 (43-88)
BMI	26.54 ± 5.11 (17.81-39.10)
Waist circumference (cm)	89.45 ± 13.13 (60.00-121.00)
Gender	Female 78 (96.30); male 3 (3.70)
Coronary artery disease	2 (2.50)
Acute coronary syndrome	2 (2.50)
History of stroke	4 (5)
Peripheral arterial disease	1 (1.30)
Complete biochemical response	44 (55)
Advanced liver fibrosis F3/F4	19 (23.50)
Metabolic syndrome	33 (40.74)
MASLD	39 (48.15)
AST (% of ULN)	93.51 ± 39.90 (45.00-215.00)
ALT (% of ULN)	85.03 ± 60.44 (25.00-350.00)
GGT (% of ULN)	186.39 ± 217.55 (34.92-1506.35)
ALP (% of ULN)	102.52 ± 54.40 (38.50-326.50)
Bil-T (μmol/L)	12.91 ± 6.08 (5.60-39.70)
Bil-C (μmol/L)	2.84 ± 2.01 (1.15-14.60)
Glucose (mmol/L)	5.57 ± 1.37 (4.10-12.40)
C-peptide (ng/mL)	2.08 ± 1.2 (0.09-7.36)
HOMA-IR	5.51 ± 2.64 (2.40-16.32)
TC (mmol/L)	5.49 ± 1.21 (3.33-9.12)
HDL-C (mmol/L)	1.71 ± 0.40 (0.84-2.79)
LDL-C (mmol/L)	3.40 ± 0.90 (1.87-5.75)
TG (mmol/L)	1.38 ± 1.24 (0.47-9.20)
Platelets (× 109/L)	247.48 ± 79.73 (44-489.00)
Adiponectin (pg/mL)	2668.94 ± 2615.75 (367.15-12457.60)
Leptin (ng/mL)	1.99 ± 3.16 (0.23-21.97)
CAP (dB/m)	236.83 ± 59.09 (108.00-400.00)
Liver stiffness (TE, kPa)	8.16 ± 5.35 (2.60-32.60)
L/A ratio	2.05 ± 4.59 (0.02-28.56)

BMI: Body mass index; MASLD: Metabolic dysfunction-associated steatotic liver disease; AST: Aspartate aminotransferase; ULN: Upper limit of normal; ALT: Alanine aminotransferase; GGT: Gamma-glutamyl transferase; ALP: Alkaline phosphatase; Bil-T: Total bilirubin; Bil-C: Conjugated bilirubin; HOMA-IR: Homeostatic model assessment of insulin resistance; TC: Total cholesterol; HDL-C: High-density lipoprotein cholesterol; LDL-C: Low density lipoprotein-cholesterol; TG: Triglycerides; CAP: Controlled attenuation parameter; TE: Transient elastography; L/A ratio: Leptin-to-adiponectin ratio.