Predictive tool for evident histological liver injury in chronic hepatitis B patients: Development and validation

Figure 4 Identification of immune-related biomarkers for chronic hepatitis B using gene expression profiling. A and B: Volcano plot showing the heatmap of top 30 differential genes upregulated and downregulated and differentially expressed genes in chronic hepatitis B (CHB) patients vs healthy controls; C: Gene Ontology (GO) functional annotation of signature genes; D-F: Functional annotation of the Kyoto Encyclopedia of Genes and Genomes (KEGG) signaling pathway of signature genes. For all enriched GO and KEGG terms, P < 0.05; G: AGE-RAGE signaling pathway in CHB complications; H: Protein-protein interaction network regulation of genes in CHB.