Dynamic immune response and its influencing factors in COVID-19 patients with non-alcoholic fatty liver disease: A cohort study

Table 7 Multivariable linear regression analysis of factors influencing lymphocyte subset counts in coronavirus disease 2019 patients with non-alcoholic fatty liver disease

		Β	SD	Beta	t	P value
CD3+ (cells/μL)	Age	-4.908	2.731	-0.088	-1.797	0.073
	COVID-19 severity	-450.591	175.134	-0.101	-2.573	0.01
	BMI	20.825	7.259	0.107	2.869	0.004
	IFG	-227.875	81.150	-0.152	-2.808	0.005
	Liver fibrosis	-324.154	71.100	-0.200	-4.599	< 0.001
CD3+CD4+ (cells/μL)	Age	0.507	1.778	0.014	0.285	0.776
	COVID-19 severity	-242.804	114.044	-0.085	-2.129	0.034
	BMI	11.363	4.690	0.091	2.423	0.016
	IFG	-138.203	52.844	-0.144	-2.615	0.009
	Liver fibrosis	-211.795	46.299	-0.204	-4.574	< 0.001
CD3+CD8+ (cells/μL)	Age	-4.062	1.201	-0.169	-3.381	< 0.001
	COVID-19 severity	-171.379	77.042	-0.089	-2.224	0.027
	BMI	9.546	3.197	0.113	2.986	0.003
	IFG	-80.441	35.698	-0.124	-2.253	0.025
	Liver fibrosis	-100.665	31.227	-0.144	-3.218	0.001
LY (cells/μL)	Age	-7.529	3.715	-0.100	-2.027	0.043
	COVID-19 severity	-696.257	238.256	-0.116	-2.922	0.004
	BMI	33.191	9.801	0.126	3.386	< 0.001
	IFG	-233.764	110.399	-0.116	-2.117	0.035
	Liver fibrosis	-390.922	128.213	-0.267	-2.570	< 0.001
CD19+ (cells/μL)	Age	-0.690	0.967	-0.037	-0.714	0.476
	COVID-19 severity	-98.248	62.003	-0.065	-1.585	0.114
	BMI	7.508	2.517	0.113	2.983	0.003
	IFG	-23.139	28.730	-0.046	-0.805	0.421
	Liver fibrosis	-46.090	25.172	-0.084	-1.831	0.068
CD56+ (cells/μL)	Age	-1.478	0.733	-0.106	-1.880	0.044
	COVID-19 severity	-88.335	46.978	-0.080	-1.880	0.061
	BMI	5.588	1.869	0.116	2.990	0.003
	IFG	-24.824	21.768	-0.066	-1.140	0.255
	Liver fibrosis	-3.042	19.072	-0.008	-0.159	0.873

Liver fibrosis: < F2: Non-significant liver fibrosis; ≥ F2: Significant liver fibrosis; ≥ F4: Cirrhosis. The number of comorbidities (0, 1, 2, 3 and more). LY: Lymphocyte counts; COVID-19: Coronavirus disease 2019; BMI: Body mass index; IFG: Impaired fasting glucose.