Performance of three clinical scores for steatosis and steatohepatitis and their interaction with metabolic syndrome in obese individuals

Table 2 Results of the clinical scores for evaluating each histopathological condition

Score	AUROC (95%CI)	Cut-off	Se (95%CI)1	Sp (95%CI)1	PPV (95%CI)1	NPV (95%CI)1	+LR (95%CI)	-LR (95%CI)
Any steatosis
NLFS	0.676 (0.563-0.790)	-0.64	83% (72-91)	31% (15-51)	73% (62-83)	45% (23-68)	1.21 (0.93-1.58)	0.54 (0.25-1.15)
		0.253	74% (62-84)	59% (39-76)	80% (68-89)	50% (32-68)	1.79 (1.14-2.83)	0.44 (0.26-0.73)
HSI	0.540 (0.406-0.674)	36	100% (95-100)	0% (0-12)	69% (59-79)	NA (0-100)	1.00 (1.00-1.00)	NA (NA-NA)
		53.4	68% (56-79)	48% (29-67)	75% (62-85)	40% (24-58)	1.32 (0.89-1.94)	0.66 (0.39-1.10)
FLI	0.468 (0.348-0.588)	60	100% (95-100)	0% (0-12)	69% (59-79)	NA (0-100)	1.00 (1.00-1.00)	NA (NA-NA)
		99.5	12% (5-22)	93% (76-99)	73% (39-94)	31% (21-42)	1.17 (0.33-4.10)	0.98 (0.84-1.14)
Moderate-to-severe steatosis
NLFS	0.671 (0.542-0.822)	0.16	80% (52-96)	38% (27-49)	19% (10-31)	91% (76-98)	1.28 (0.94-1.74)	0.53 (0.19-1.53)
		1.83	67% (38-88)	66% (55-76)	27% (14-44)	91% (81-97)	1.98 (1.23-3.17)	0.50 (0.24-1.05)
HSI	0.659 (0.522-0.796)	36	100% (78-100)	0% (0-5)	16% (9-25)	NA (0-0)	1.00 (1.00-1.00)	NA (NA-NA)
		57	60% (32-84)	72% (61-82)	29% (14-48)	91% (81-96)	2.18 (1.26-3.76)	0.55 (0.29-1.04)
FLI	0.700 (0.574-0.825)	60	100% (78-100)	0% (0-5)	16% (9-25)	NA (0-100)	1.00 (1.00-1.00)	NA (NA-NA)
		98.5	80% (52-96)	51% (39-62)	23% (13-37)	93% (81-99)	1.60 (1.14-2.24)	0.40 (0.14-1.13)
MASH
NLFS	0.671 (0.507-0.836)	-0.64	80% (52-96)	21% (13-32)	16% (9-26)	85 (62-97)	1.02 (0.77-1.34)	0.94 (0.31-2.82)
		0.16	80% (52-96)	38% (27-49)	19% (10-31)	91% (76-98)	1.28 (0.94-1.74)	0.53 (0.19-1.53)
		2.43	67% (38-88)	78% (67-86)	36% (19-56)	93% (83-98)	2.96 (1.72-5.09)	0.43 (0.21-0.98)
HSI	0.625 (0.482-0.768)	36	100% (78-100)	0% (0-5)	16% (9-25)	NA (0-100)	1.00 (1.00-1.00)	NA (NA-NA)
		56.2	60% (32-84)	65% (54-75)	24% (12-41)	90% (79-96)	1.71 (1.03-2.85)	0.62 (0.32-1.17)
FLI	0.639 (0.502-0.776)	60	100% (78-100)	0% (0-5)	16% (9-25)	NA (0-100)	1.00 (1.00-1.00)	NA (NA-NA)
		98.5	73% (45-92)	49% (37-60)	21% (11-35)	91% (78-97)	1.43 (0.99-2.08)	0.55 (0.23-1.30)

¹Values presented as percentages.

AUROC: Area under the receiver operating characteristic curve; CI: Confidence interval; FLI: Fatty liver index; HSI: Hepatic steatosis index; +LR: Positive likelihood ratio; -LR: Negative likelihood ratio; MASH: Metabolic dysfunction-associated steatohepatitis; NA: Not available; NLFS: Non-alcoholic fatty liver disease liver fat score; NPV: Negative predictive value; PPV: Positive predictive value; Se: Sensitivity; Sp: Specificity.