Changes in lipid biomarkers, liver stiffness and steatosis following sodium-glucose cotransporter two inhibitor therapy in type two diabetes

doi:10.4254/wjh.125505

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World Journal of Hepatology

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1948-5182

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World J Hepatol. Oct 27, 2026; 18(10): 125505
Published online Oct 27, 2026. doi: 10.4254/wjh.125505

Table 5 Distribution of participants by fibrosis stage, steatosis stage, nonalcoholic fatty liver disease fibrosis score and Fibrosis-4 index risk categories at baseline and after 6 months of sodium-glucose cotransporter 2 inhibitor therapy, n (%)

Parameter		Baseline	6 months	P value
Fibrosis stage	F0/F1	54 (80.6)	60 (89.6)	0.16¹
	F2	2 (3)	3 (4.5)
	F3	3 (4.5)	1 (1.5)
	F4	8 (11.9)	3 (4.5)
Steatosis stage	S0	13 (21.3)	16 (26.2)	0.89¹
	S1	15 (24.6)	15 (24.6)
	S2	18 (29.5)	15 (24.6)
	S3	15 (24.6)	15 (24.6)
NFS risk category	Low	9 (14.3)	9 (14.3)	0.85²
	Intermediate	42 (66.7)	40 (63.5)
	High	12 (19.0)	14 (22.2)
FIB-4 risk category	Low	53 (79.1)	52 (77.6)	0.81²
	Intermediate	11 (16.4)	11 (16.4)
	High	3 (4.5)	4 (6.0)

¹McNemar-Bowker test.

²Marginal homogeneity test.

FIB-4: Fibrosis-4 index; NFS: Nonalcoholic fatty liver disease fibrosis score.

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Citation: Khaznadar F, Bojanić K, Khaznadar O, Jurić A, Hefer M, Kralik K, Petrović A, Hrženjak A, Lončar A, Steiner J, Smolić M, Smolić R. Changes in lipid biomarkers, liver stiffness and steatosis following sodium-glucose cotransporter two inhibitor therapy in type two diabetes. World J Hepatol 2026; 18(10): 125505
URL: https://www.wjgnet.com/1948-5182/full/v18/i10/125505.htm
DOI: https://dx.doi.org/10.4254/wjh.125505

Khaznadar F, Bojanić K, Khaznadar O, Jurić A, Hefer M, Kralik K, Petrović A, Hrženjak A, Lončar A, Steiner J, Smolić M, Smolić R. Changes in lipid biomarkers, liver stiffness and steatosis following sodium-glucose cotransporter two inhibitor therapy in type two diabetes. World J Hepatol 2026; 18(10): 125505 [DOI: 10.4254/wjh.125505]

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