Changes in lipid biomarkers, liver stiffness and steatosis following sodium-glucose cotransporter two inhibitor therapy in type two diabetes

doi:10.4254/wjh.125505

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World Journal of Hepatology

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1948-5182

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World J Hepatol. Oct 27, 2026; 18(10): 125505
Published online Oct 27, 2026. doi: 10.4254/wjh.125505

Table 4 Changes in liver stiffness assessed by two-dimensional shear wave elastography, steatosis assessed by ultrasound-guided attenuation parameter, and lipogenesis biomarkers measured by enzyme-linked immunosorbent assay from baseline to 6 months after initiation of sodium-glucose cotransporter 2 inhibitor therapy

Parameter	Baseline, median (IQR)	6 months, median (IQR)	Difference¹	95%CI	P value²
Ultrasound imaging
E Median 2D-SWE (kPa)	6.2 (5.7-7.5)	6.1 (5.4-6.8)	-0.51	-0.93 to -0.21	< 0.001^a
Med UGAP (dB/cm/MHz)	0.7 (0.7-0.8)	0.7 (0.6-0.8)	-0.02	-0.04 to 0.01	0.14
E IQR 2D-SWE (kPa)	1.3 (0.8-2.1)	0.1 (0-0.1)	-0.37	-0.69 to -0.09	0.005^a
IQR UGAP (dB/cm/MHz)	0.05 (0.04-0.07)	0.06 (0.04-0.07)	0.01	-0.005 to 0.02	0.24
ELISA
PPAR-γ (ng/L)	895 (727.8-1105.6)	565.4 (336.7-839.8)	-297.03	-399.7 to -196.7	< 0.001^a
PPAR-α (ng/L)	1667 (1133.7-3223.7)	1294 (779-2514)	-274.8	-818.5 to 308.7	0.38
SREBP-1c (ng/L)	5151.5 (3037.4-6969.7)	4900 (4100-5700)	174.3	-729.2 to 1062.0	0.72
MTTP (ng/L)	198.4 (103.8-301.3)	428.9 (351.6-532.1)	233.9	183.1 to 277.4	< 0.001^a

¹Hodges-Lehmann difference of median.

²Wilcoxon test.

^aP < 0.001.

UGAP: Ultrasound-guided attenuation parameter; ELISA: Enzyme-linked immunosorbent assay; PPAR-γ: Peroxisome proliferator-activated receptor gamma; PPAR-α: Peroxisome proliferator-activated receptor alpha; SREBP-1c: Sterol regulatory element-binding protein-1c; MTTP: Microsomal triglyceride transfer protein; IQR: Interquartile range; CI: Confidence interval; 2D-SWE: Two-dimensional shear wave elastography.

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Citation: Khaznadar F, Bojanić K, Khaznadar O, Jurić A, Hefer M, Kralik K, Petrović A, Hrženjak A, Lončar A, Steiner J, Smolić M, Smolić R. Changes in lipid biomarkers, liver stiffness and steatosis following sodium-glucose cotransporter two inhibitor therapy in type two diabetes. World J Hepatol 2026; 18(10): 125505
URL: https://www.wjgnet.com/1948-5182/full/v18/i10/125505.htm
DOI: https://dx.doi.org/10.4254/wjh.125505

Khaznadar F, Bojanić K, Khaznadar O, Jurić A, Hefer M, Kralik K, Petrović A, Hrženjak A, Lončar A, Steiner J, Smolić M, Smolić R. Changes in lipid biomarkers, liver stiffness and steatosis following sodium-glucose cotransporter two inhibitor therapy in type two diabetes. World J Hepatol 2026; 18(10): 125505 [DOI: 10.4254/wjh.125505]

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