Gut microbiome in patients with cirrhosis and clinically significant portal hypertension: A pilot study

doi:10.4254/wjh.124666

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World Journal of Hepatology

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1948-5182

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World J Hepatol. Oct 27, 2026; 18(10): 124666
Published online Oct 27, 2026. doi: 10.4254/wjh.124666

Table 2 Comparison of baseline parameters between patients with and without fecal pathobionts, n (%)/median (range)

Baseline parameters	Pts with pathobionts (n = 20)	Pts without pathobionts (n = 5)	P value
Age, years	61 (40-76)	66 (65-75)	NS
Sex, males	17 (85)	4 (80)	NS
Etiology
HBV	0	1 (20)	NS
HCV	3 (15)	2 (40)	NS
MetALD	12 (70)	1 (20)	NS
MASLD	0	1 (20)	NS
MELD	9 (7-23)	9 (8-10)	NS
PH features
No EV	1 (17)	0	NS
EV F1	11 (50)	3 (60)	NS
EV F2	6 (33)	1 (20)	NS
Previous EVL	2 (17)	1 (20)	NS
Total bilirubin, mg/dL	1.1 (0.7-10)	1.3 (1.2-2.0)	NS
AST, U/L	25 (21-69)	26 (23-27)	NS
ALT, U/L	22 (17-56)	27 (22-29)	NS
GGT, U/L	60 (27-551)	20 (20-26)	NS
Platelet, n/μL	67 × 10³ (32-222 × 10³)	73 × 10³ (55-79 × 10³)	NS
T2DM	17 (85)	0	< 0.01^a
BMI	31 (24-46)	25.5 (23-27)	NS
Splenomegaly¹	20 (100)	5 (100)	NS
Liver elastography (kPa)	23 (11-64)	17 (11-37)	NS

¹pleen length > 12 cm.

^aFisher exact test.

Pts: Patients; HBV: Hepatitis B virus; HCV: Hepatitis C virus; AST: Aspartate amino transaminase; ALT: Alanine amino transaminase; GGT: Gamma-glutamyl transpeptidase; MetALD: Metabolic disfunction and alcohol related liver disease; MASLD: Metabolic disfunction associated steatosic liver disease; MELD: Model of end stage liver diseases; PH: Portal hypertension; EV: Esophageal varices; EVL: Esophageal varices ligation; BMI: Body mass index; T2DM: Type 2 diabetes mellitus.

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Citation: Colucci G, Stella S, Castagnetti A, Di Rito L, Lucà M, Tosetti G, D’Ambrosio R, Lampertico P. Gut microbiome in patients with cirrhosis and clinically significant portal hypertension: A pilot study. World J Hepatol 2026; 18(10): 124666
URL: https://www.wjgnet.com/1948-5182/full/v18/i10/124666.htm
DOI: https://dx.doi.org/10.4254/wjh.124666

Colucci G, Stella S, Castagnetti A, Di Rito L, Lucà M, Tosetti G, D’Ambrosio R, Lampertico P. Gut microbiome in patients with cirrhosis and clinically significant portal hypertension: A pilot study. World J Hepatol 2026; 18(10): 124666 [DOI: 10.4254/wjh.124666]

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