Gut microbiome in patients with cirrhosis and clinically significant portal hypertension: A pilot study

doi:10.4254/wjh.124666

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Hepatol. Oct 27, 2026; 18(10): 124666
Published online Oct 27, 2026. doi: 10.4254/wjh.124666

Table 1 Patients’ main clinical features, n (%)/median (range)

Baseline parameters	Patients (n = 25)
Age, years	65 (40-72)
Male sex	20 (80)
Etiology
HBV	1 (4)
HCV	5 (20)
MetALD	18 (72)^a
MASLD	1 (4)
MELD	10 (6-16)
PH features
No EV	1 (4)
EV F1	14 (56)
EV F2	6 (24)
Previous EVL	4 (16)
Total bilirubin, mg/dL	1.2 (0.8-3.5)
AST, U/L	31 (22-82)
ALT, U/L	30 (15-57)
GGT, U/L	88 (24-369)
Platelet, n/μL	72 × 10³ (40 × 10³ - 169 × 10³)
T2DM	21 (84)
BMI	31 (24-46)
Splenomegaly¹	21 (84)
Liver elastography (kPa)	24.5 (18-64)

^aP < 0.01 metabolic disfunction and alcohol related liver disease more prevalent than hepatitis C virus + hepatitis B virus.

¹Spleen length > 12 cm.

HBV: Hepatitis B virus; HCV: Hepatitis C virus; AST: Aspartate amino transaminase; ALT: Alanine amino transaminase; GGT: Gamma-glutamyl transpeptidase; MetALD: Metabolic disfunction and alcohol related liver disease; MASLD: Metabolic disfunction associated steatosic liver disease; MELD: Model of end stage liver diseases; PH: Portal hypertension; EV: Esophageal varices; EVL: Esophageal varices ligation; BMI: Body mass index; T2DM: Type 2 diabetes mellitus.

Full Size Table

Citation: Colucci G, Stella S, Castagnetti A, Di Rito L, Lucà M, Tosetti G, D’Ambrosio R, Lampertico P. Gut microbiome in patients with cirrhosis and clinically significant portal hypertension: A pilot study. World J Hepatol 2026; 18(10): 124666
URL: https://www.wjgnet.com/1948-5182/full/v18/i10/124666.htm
DOI: https://dx.doi.org/10.4254/wjh.124666

Colucci G, Stella S, Castagnetti A, Di Rito L, Lucà M, Tosetti G, D’Ambrosio R, Lampertico P. Gut microbiome in patients with cirrhosis and clinically significant portal hypertension: A pilot study. World J Hepatol 2026; 18(10): 124666 [DOI: 10.4254/wjh.124666]

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