Risk factors and predictive model for hepatitis B virus deoxyribonucleic acid elevation in mid-to-late pregnancy with low viremia

doi:10.4254/wjh.124577

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World Journal of Hepatology

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1948-5182

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Hepatol. Oct 27, 2026; 18(10): 124577
Published online Oct 27, 2026. doi: 10.4254/wjh.124577

Table 2 Clinical characteristics of elevated and non-elevated groups, n (%)

Factor	Total cases (n = 430)	Non-elevated groups (n = 272)	Elevated groups (n = 158)	P value
HBeAg				0.021
Negative	402 (93.49)	260 (95.59)	142 (89.87)
Positive	28 (6.51)	12 (4.41)	16 (10.13)
HBV DNA (IU/mL)				< 0.001
< 100	228 (53.02)	181 (66.54)	47 (29.75)
≥ 100	202 (46.98)	91 (33.46)	111 (70.25)
TBA, µmol/L	2.60 (1.46, 4.25)	2.60 (1.40, 4.00)	2.65 (1.80, 4.45)	0.454
TBIL, µmol/L	5.75 (4.38, 7.62)	5.80 (4.25, 7.80)	5.65 (4.38, 7.50)	0.530
DBIL, µmol/L	2.50 (1.91, 3.12)	2.50 (2.00, 3.20)	2.50 (1.90, 3.10)	0.697
IBIL, µmol/L	3.10 (2.20, 4.70)	3.10 (2.20, 4.95)	3.10 (2.15, 4.55)	0.636
AST, U/L	15.50 (13.50, 19.60)	15.40 (13.20, 19.60)	16.20 (13.60, 19.60)	0.643
AST < 19	251 (58.37)	159 (58.46)	92 (58.23)	0.352
AST ≥ 19	100 (23.26)	58 (21.32)	42 (26.58)
ALT, U/L	13.60 (9.80, 18.88)	13.60 (9.75, 18.75)	13.50 (9.75, 18.91)	0.915
ALT < 19	232 (53.95)	140 (51.47)	92 (58.23)	0.958
ALT ≥ 19	75 (17.44)	45 (16.54)	30 (18.99)
TP, g/L	65.71 ± 4.29	65.43 ± 3.85	66.04 ± 4.81	0.555
ALB, g/L	36.10 ± 3.81	36.11 ± 3.76	35.80 ± 3.92	0.980
GLB, g/L	30.30 ± 3.20	29.95 ± 318	30.68 ± 3.22	0.343
HGB, g/L	120.00 (113.00, 127.00)	120.00 (113.00, 127.75)	120.00 (113.50, 126.00)	0.662
PLT, × 10⁹/L	230.00 (201.00, 263.25)	232.00 (201.00, 264.00)	226.00 (201.50, 263.00)	0.644
WBC, × 10⁹/L	8.61 (7.54, 10.20)	8.60 (7.58, 10.39)	8.61 (7.36, 9.82)	0.455
TC, mmol/L	4.73 (4.12, 5.26)	4.69 (4.13, 5.23)	4.83 (4.06, 5.33)	0.622
TG, mmol/L	1.39 (1.12, 1.82)	1.44 (1.17, 1.87)	1.28 (1.03, 1.68)	0.025
HDL-C, mmol/L	1.71 ± 0.29	1.70 ± 0.28	1.72 ± 0.61	0.678
LDL-C, mmol/L	2.36 (2.02, 2.76)	2.36 (2.10, 2.70)	2.38 (1.90, 2.81)	0.920
HbA1c, %	5.10 (5.00, 5.30)	5.10 (5.00, 5.30)	5.10 (4.90, 5.30)	0.429
< 6.0	276 (64.19)	177 (65.07)	99 (62.66)	0.060
≥ 6.0	2 (0.47)	0 (0)	2 (1.27)
Cr, µmol/L	49.00 (44.00, 54.00)	48.70 (43.00, 54.00)	50.00 (44.00, 55.00)	0.333
PT, seconds	12.50 (11.10, 12.90)	12.40 (11.20, 12.88)	12.50 (11.05, 13.000	0.339
APTT, seconds	32.40 (28.80, 34.70)	32.45 (28.85, 34.78)	32.20 (28.80, 34.70)	0.883
INR	0.95 (0.92, 0.99)	0.95 (0.92, 0.99)	0.96 (0.92, 0.99)	0.380

HBeAg: Hepatitis B virus e antigen; HBV DNA: Hepatitis B virus deoxyribonucleic acid; TBA: Total bile acid; TBIL: Total bilirubin; DBIL: Direct bilirubin; IBIL: Indirect bilirubin; AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; TP: Total protein; ALB: Albumin; GLB: Globulin; HGB: Hemoglobin; PLT: Platelet; WBC: White blood cell; TC: Total cholesterol; TG: Triglyceride; HDL-C: High-density lipoprotein cholesterol; LDL-C: Low-density lipoprotein cholesterol; HbA1c: Glycated hemoglobin; Cr: Creatinine; PT: Prothrombin time; APTT: Activated partial thromboplastin time; INR: International normalized ratio.

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Citation: Chen Z, Chen H, Jie B, Peng T, Lin Y, Geng Y, Shen Y, Deng Y, Xie D, Yang L, Ouyang S. Risk factors and predictive model for hepatitis B virus deoxyribonucleic acid elevation in mid-to-late pregnancy with low viremia. World J Hepatol 2026; 18(10): 124577
URL: https://www.wjgnet.com/1948-5182/full/v18/i10/124577.htm
DOI: https://dx.doi.org/10.4254/wjh.124577

Chen Z, Chen H, Jie B, Peng T, Lin Y, Geng Y, Shen Y, Deng Y, Xie D, Yang L, Ouyang S. Risk factors and predictive model for hepatitis B virus deoxyribonucleic acid elevation in mid-to-late pregnancy with low viremia. World J Hepatol 2026; 18(10): 124577 [DOI: 10.4254/wjh.124577]

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