Proactive antithyroid therapy improves survival in hyperthyroidism-induced liver injury: A real-world cohort study

Figure 2 Comparison of clinical parameters between antithyroid drug-treated and non-antithyroid drug groups before and after treatment. A-D: They compare the indicators of blood routine, coagulation function, thyroid function, and liver function before and after treatment in the non-antithyroid drug treatment group, including white blood cell, red blood cell, neutrophil (NEUT), platelet (PLT), hemoglobin, international normalized ratio, prothrombin time (PT), activated partial thromboplastin time (APTT), thyroid-stimulating hormone (TSH), free triiodothyronine (FT3), free thyroxine (FT4), thyrotropin receptor antibody (TRAb), thyroid peroxidase antibody, thyroglobulin antibody, albumin (ALB), alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TBIL), direct bilirubin (DBIL), total thyroxine (TT4), and alkaline phosphatase (ALP). Among these, APTT, ALB, ALT, AST, TBIL, TT4, and ALP all showed P < 0.05, indicating statistically significant differences before and after treatment; E-H: They compare the indicators of blood routine, coagulation function, thyroid function, and liver function before and after treatment in the antithyroid drug treatment group, including white blood cell, red blood cell, NEUT, PLT, hemoglobin, international normalized ratio, PT, APTT, TSH, FT3, FT4, TRAb, thyroid peroxidase antibody, thyroglobulin antibody, ALB, ALT, AST, TBIL, and DBIL. Among these, NEUT, TT3, TSH, PT, APTT, FT3, FT4, TRAb, ALB, ALT, AST, TBIL, DBIL, PLT, TT4, ALP, and GGT all showed P < 0.05, indicating statistically significant differences before and after treatment. It presents P values for the differences between the two groups [antithyroid drug (+) vs antithyroid drug (-)] at pre-treatment and post-treatment time points for each laboratory indicator. P values were calculated using an appropriate statistical test (e.g., independent t-test or Mann-Whitney U test). A P value < 0.05 was considered statistically significant. WBC: White blood cell; RBC: Red blood cell; NEUT: Neutrophil; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; ALB: Albumin; TP: Total protein; TBIL: Total bilirubin; DBIL: Direct bilirubin; ALP: Alkaline phosphatase; GGT: Γ-glutamyl transferase; FT3: Free triiodothyronine; FT4: Free thyroxine; TT3: Total triiodothyronine; TT4: Total thyroxine; TRAb: Thyrotropin receptor antibody; A-TPO: Thyroid peroxidase antibody; TgAb: Thyroglobulin antibody; PT: Prothrombin time; APTT: Activated partial thromboplastin time; INR: International normalized ratio; TSH: Thyroid stimulating hormone; PLT: Platelet; HGB: Hemoglobin; ATD: Antithyroid drug.