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Publication Name
World Journal of Hepatology
ISSN
1948-5182
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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Prospective Study
Copyright: ©Author(s) 2026.
World J Hepatol. Oct 27, 2026; 18(10): 123267
Published online Oct 27, 2026. doi: 10.4254/wjh.123267
Table 3 Comparison of laboratory findings between patients with hyperthyroidism-induced liver injury with antithyroid drug exposure and those without antithyroid drug exposure, n (%)/median (interquartile range)
Items
Total (n = 140)
ATD (-) (n = 40)
ATD (+) (n = 100)
P value
Laboratory findings pre-treatment
Blood routine
WBC (× 109/L)6.21 (5.42, 8.17)6.45 (5.61, 8.21)6.03 (5.38, 8.02)0.570
RBC (× 1012/L)3.83 (2.94, 4.32)3.68 (2.92, 4.21)3.95 (2.98, 4.54)0.161
PLT (× 109/L)142.3 (106.5, 204.8)164.8 (114.4, 210.0)136.0 (92.3, 190.4)0.172
HGB (g/L)114.3 (93.0, 130.9)111.9 (92.3, 126.6)118.1 (95.1, 132.2)0.166
NEUT (× 109/L)4.91 (2.19, 7.56)4.72 (2.12, 7.33)5.15 (2.23, 7.68)0.590
Hepatic function
ALT (μ/L)284.9 (128.6, 315.5)284.4 (128.3, 310.0)286.1 (130.4, 318.4)0.983
AST (μ/L)231.7 (105.3, 283.6)241.5 (109.2, 294.0)224.6 (102.6, 281.3)0.779
TBIL (μmol/L)272.3 (86.1, 405.4)280.9 (85.6, 451.1)269.9 (97.8, 373.9)0.810
DBIL (μmol/L)196.5 (55.8, 336.2)206.2 (50.6, 368.6)193.2 (68.1, 260.8)0.705
TP (g/L)61.92 (48.8, 76.1)62.47 (49.3, 76.3)61.54 (48.4, 75.9)0.630
ALB (g/L)28.22 (21.8, 34.6)27.81 (21.6, 34.3)28.85 (22.7, 34.9)0.246
GGT (U/L)83.28 (68.36, 105.5)74.11 (61.42, 96.32)98.34 (71.38, 118.0)0.1268
ALP (U/L)162.4 (113.6, 214.4)159.5 (109.2, 208.3)173.0 (119.2, 226.4)0.4333
Coagulation function
PT (seconds)18.87 (14.92, 24.16)18.67 (14.23, 23.62)19.05 (15.33, 25.13)0.781
APTT (seconds)48.87 (38.02, 61.24)49.91 (38.36, 62.42)48.42 (37.92, 60.67)0.631
INR1.62 (1.22, 2.15)1.61 (1.21, 2.14)1.63 (1.23, 2.16)0.906
Thyroid function
FT3 (pmol/L)10.20 (5.12, 13.62)8.71 (3.24, 13.58)11.63 (6.50, 14.13)0.077
FT4 (pmol/L)19.41 (8.12, 24.55)17.02 (3.76, 24.00)21.72 (10.76, 25.00)0.067
TT3 (nmol/L)3.50 (2.47, 4.36)3.22 (2.30, 4.20)3.77 (2.89, 4.56)0.114
TT4 (nmol/L)127.2 (96.5, 150.3)122.8 (83.5, 146.0)139.7 (110.0, 156.9)0.091
TSH (μIU/mL)0.24 (0.01, 0.42)0.32 (0.01, 0.51)0.17 (0.01, 0.34)0.198
TRAb (IU/mL)15.08 (8.16, 17.00)15.22 (7.80, 18.20)14.99 (9.10, 16.80)0.904
TgAb (μ/mL)210.6 (29.1, 370.3)222.1 (34.1, 349.0)202.6 (27.9, 400.0)0.748
A-TPO (μ/mL)501.2 (39.3, 913.6)533.7 (39.5, 990.0)477.9 (39.2, 880.0)0.5634
Laboratory findings post-treatment
Blood routine
WBC (× 109/L)5.62 (3.67, 7.03)5.85 (3.38, 7.76)5.40 (4.01, 6.64)0.446
RBC (× 1012/L)3.93 (3.10, 4.57)3.57 (2.71, 4.35)4.25 (3.64, 4.83)0.003
PLT (× 109/L)180.0 (93.4, 269.3)155.7 (79.0, 209.0)218.2 (127.0, 312.0)0.021
HGB (g/L)112.2 (96.0, 128.2)108.0 (87.0, 121.9)118.6 (104.0, 133.5)0.061
NEUT (× 109/L)3.36 (2.01, 4.33)3.58 (1.87, 4.53)3.23 (2.18, 4.02)0.456
Hepatic function
ALT(μ/L)48.20 (29.0, 63.4)51.64 (27.0, 72.3)45.34 (31.0, 58.3)0.358
AST (μ/L)56.18 (31.2, 70.8)59.73 (33.5, 72.8)54.25 (29.5, 69.8)0.558
TBIL (μmol/L)94.0 (21.8, 121.3)117.6 (23.0, 139.5)70.18 (20.0, 107.3)0.025
DBLI (μmol/L)71.69 (11.0, 95.2)90.81 (11.5, 123.6)53.43 (10.5, 75.2)0.033
TP (g/L)66.18 (59.9, 73.4)64.36 (57.9, 70.2)69.03 (63.1, 77.0)0.024
ALB (g/L)34.28 (31.0, 38.0)34.09 (30.4, 38.3)34.69 (32.2, 37.9)0.566
GGT (U/L)72.17 (42.6, 83.0)85.11 (57.8, 90.0)59.14 (36.6, 66.0)0.039
ALP (U/L)106.2 (75.0, 124.5)120.6 (87.0, 134.0)91.90 (65.0, 113.5)0.0005
Coagulation function
PT (seconds)14.64 (13.1, 15.3)15.90 (13.6, 17.6)13.91 (12.5, 15.3)0.007
APTT (seconds)41.00 (36.2, 46.7)43.49 (36.0, 48.3)40.40 (36.5, 42.2)0.135
INR1.21 (0.98, 1.31)1.34 (1.07, 1.48)1.12 (0.90, 1.28)0.017
Thyroid function
FT3 (pmol/L)6.35 (4.00, 9.21)7.13 (4.00, 11.00)5.49 (4.00, 6.46)0.035
FT4 (pmol/L)7.12 (2.03, 12.30)8.90 (1.86, 16.12)6.09 (2.12, 9.00)0.033
TT3 (nmol/L)2.49 (1.81, 3.02)2.58 (1.89, 3.12)2.42 (1.79, 2.93)0.472
TT4 (nmol/L)64.12 (23.5, 82.1)71.82 (23.4, 91.0)55.53 (23.7, 78.0)0.023
TSH (μIU/mL)1.02 (0.21, 1.54)0.52 (0.01, 0.74)1.53 (0.70, 2.40)< 0.0001
TRAb (IU/mL)8.37 (3.50, 10.04)11.43 (4.71, 15.82)5.15 (2.53, 7.01)< 0.0001
TgAb (μ/mL)140.6 (23.5, 260.3)183.9 (29.3, 336.0)109.1 (19.2, 155.3)0.071
A-TPO (μ/mL)382.1 (42.5, 712.0)478.5 (56.0, 768.0)317.6 (39.5, 678.0)0.061
WBC: White blood cell; RBC: Red blood cell; PLT: Platelet; NEUT: Neutrophil; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; ALB: Albumin; TP: Total protein; TBIL: Total bilirubin; DBIL: Direct bilirubin; ALP: Alkaline phosphatase; GGT: Γ-glutamyl transferase; FT3: Free triiodothyronine; FT4: Free thyroxine; TT3: Total triiodothyronine; TT4: Total thyroxine; TRAb: Thyrotropin receptor antibody; A-TPO: Thyroid peroxidase antibody; TgAb: Thyroglobulin antibody; PT: Prothrombin time; APTT: Activated partial thromboplastin time; INR: International normalized ratio; ATD: Antithyroid drug; TSH: Thyroid stimulating hormone; HGB: Hemoglobin.
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