Current management strategies for sarcopenia and frailty in cirrhosis: Missing link in transplant candidacy

Table 2 Diagnostic tools and cutoffs for assessing frailty and sarcopenia in cirrhosis

Investigation	Defined cutoff	Correlation with pretransplant mortality
Short physical performance battery	Frail = score less than or equal to 9/12	Yes (> 65 years age)
Liver Frailty Index score	Frail = 4.5	Yes
6-minute walk test	< 250 m	Yes, mortality reduces by 52%
Bioelectrical impedance analysis	ASMI; Males: < 7.0 kg/m2; Females: < 5.7 kg/m2	Yes
Hand grip test	Males: 26 kg; Females: 18 kg	Yes
Skeletal muscle index	Males: < 50 cm2/m2; Females: < 39.50 cm2/m2	Yes
Appendicular lean mass-height adjusted	Males: < 6.57 kg/50 m2; Females: < 4.61 kg/m2	Yes
DEXA upper limb lean mass-height-adjusted	Males: < 1.6 kg/m2	Yes (males)
MRI: Fat-free muscle area at the level of the superior mesenteric artery	Males: FFMA < 3197.50 mm2; Females: FFMA < 2895.50 mm2

DEXA: Dual energy X-absorption study; FFMA: Fat-free muscle area; MRI: Magnetic resonance imaging; ASMI: Appendicular Skeletal Muscle Index.