Not always autoimmune hepatitis: Hepatic steatosis is associated with autoantibodies positivity in patients with hepatocellular dysfunction

Table 3 Factors associated with autoimmune hepatitis diagnosis in patients with anti-nuclear antibodies positivity, n (%)/mean ± SD

Variable	AIH diagnosis confirmed (n = 36)	AIH diagnosis not confirmed (n = 31)	P value
Gender
Female	30 (83.3)	18 (58.1)	0.022
Male	6 (16.7)	13 (41.9)
Age (years)	55 ± 16	58 ± 13	0.333
Arterial hypertension	13 (36.1)	14 (45.2)	0.451
T2DM	5 (13.9)	11 (35.5)	0.039
Dyslipidaemia	13 (36.1)	16 (51.6)	0.202
Obesity	8 (22.2)	14 (45.2)	0.046
Previous cardiovascular event	2 (5.6)	2 (6.5)	1.000
Other autoimmune disorders	4 (11.1)	1 (3.2)	0.363
Positivity of autoantibodies
SMA	7 (19.4)	1 (3.2)	0.060
Anti-LKM	2 (5.6)	1 (3.2)	1.000
Anti-LC-1	4 (11.1)	1 (3.2)	0.353
Elevated IgG levels	14 (38.9)	5 (16.1)	0.048
Total bilirubin (mg/dL), median (IQR)	0.67 (0.52)	0.68 (0.60)	0.905
AST (UI/L), median (IQR)	66 (105)	36 (40)	0.092
ALT (UI/L), median (IQR)	85 (154)	50 (54)	0.021
GGT (UI/L), median (IQR)	99 (150)	52 (94)	0.065
ALP (UI/L), median (IQR)	106 (76)	91 (48)	0.258
CAP (dB/m2)	244 ± 60	288 ± 56	0.012
LSM (kPa), median (IQR)	5.4 (3.1)	6.7 (14.9)	0.205

AIH: Autoimmune hepatitis; T2DM: Type 2 diabetes mellitus; SMA: Smooth muscle antibodies; Anti-LKM: Anti-liver kidney microsomal antibodies; Anti-LC-1: Anti-liver cytosol type 1; Anti-SLA/LP: Antibodies against soluble liver antigen/Liver pancreas autoantigen; IQR: Interquartile range; AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; GGT: Gamma-glutamyl transferase; ALP: Alkaline phosphatase; CAP: Controlled attenuation parameter; LSM: Liver stiffness measurement; IQR: Interquartile range.