Not always autoimmune hepatitis: Hepatic steatosis is associated with autoantibodies positivity in patients with hepatocellular dysfunction

doi:10.4254/wjh.v18.i1.114045

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Cohort Study

World J Hepatol. Jan 27, 2026; 18(1): 114045
Published online Jan 27, 2026. doi: 10.4254/wjh.v18.i1.114045

Table 1 Patients’ baseline characteristics, n (%)/mean ± SD

Variable	Patients’ characteristics
Gender
Female	57 (70.4)
Male	24 (29.6)
Age (years)	55 ± 15
Cardiometabolic factors
Arterial hypertension	31 (38.3)
T2DM	18 (22.2)
Dyslipidaemia	32 (39.5)
Obesity	26 (32.1)
Previous cardiovascular event	4 (4.9)
Presence of other autoimmune disorders	6 (7.4)
Positivity of autoantibodies
ANA	67 (82.7)
SMA	10 (12.3)
Anti-LKM	5 (6.3)
Anti-LC-1	6 (9.0)
Anti-SLA/LP	13 (16.0)
Elevated IgG levels	21 (29.6)
Histological findings
Hepatic steatosis	39 (48.1)
Lymphocyte infiltrate	55 (67.9)
Interface hepatitis	5 (6.2)
Emperipolesis	0 (0.0)
Hepatocyte rosettes	0 (0.0)
Histological criteria for AIH
Typical	5 (6.2)
Compatible	38 (46.9)
Atypical	38 (46.9)

T2DM: Type 2 diabetes mellitus; ANA: Anti-nuclear antibodies; SMA: Smooth muscle antibodies; Anti-LKM: Anti-liver kidney microsomal antibodies; Anti-LC-1: Anti-liver cytosol type 1; Anti-SLA/LP: Antibodies against soluble liver antigen/Liver pancreas autoantigen; AIH: Autoimmune hepatitis.

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Citation: Ferreira AI, Costa Azevedo M, Macedo Silva V, Xavier S, Magalhães J, Cotter J. Not always autoimmune hepatitis: Hepatic steatosis is associated with autoantibodies positivity in patients with hepatocellular dysfunction. World J Hepatol 2026; 18(1): 114045
URL: https://www.wjgnet.com/1948-5182/full/v18/i1/114045.htm
DOI: https://dx.doi.org/10.4254/wjh.v18.i1.114045

Ferreira AI, Costa Azevedo M, Macedo Silva V, Xavier S, Magalhães J, Cotter J. Not always autoimmune hepatitis: Hepatic steatosis is associated with autoantibodies positivity in patients with hepatocellular dysfunction. World J Hepatol 2026; 18(1): 114045 [PMID: 41640969 DOI: 10.4254/wjh.v18.i1.114045]

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