Prognostic value of dynamic changes in C-reactive protein to albumin ratio in patients with acute-on-chronic liver failure

Table 4 Predictive performance of Chinese Group on the Study of Severe Hepatitis B- C-reactive protein to albumin ratio

Prognostic model	28-day mortality original AUC (95%CI)	28-day mortality bootstrap corrected AUC (95%CI)	90-day mortality original AUC (95%CI)	90-day mortality bootstrap corrected AUC (95%CI)	P value Original	P value Bootstrap
COSSH-CAR	0.832 (0.756-0.895)	0.821 (0.793-0.849)	0.811 (0.732-0.874)	0.798 (0.767-0.829)	Reference	Reference
MELD	0.743 (0.658-0.818)	0.731 (0.698-0.764)	0.725 (0.640-0.800)	0.712 (0.679-0.745)	0.008	0.005
MELD-Na	0.768 (0.685-0.840)	0.752 (0.721-0.783)	0.751 (0.667-0.825)	0.736 (0.703-0.769)	0.015	0.012
CTP	0.721 (0.635-0.798)	0.709 (0.675-0.743)	0.708 (0.622-0.785)	0.693 (0.658-0.728)	0.002	< 0.001
COSSH-ACLF	0.786 (0.704-0.856)	0.769 (0.737-0.801)	0.772 (0.690-0.842)	0.758 (0.726-0.790)	0.027	0.023

P values for comparison with Chinese Group on the Study of Severe Hepatitis B-C-reactive protein to albumin ratio using the DeLong test for paired receiver operating characteristic curves. Bootstrap resampling performed with 1000 iterations using bias-corrected and accelerated method. AUC: Area under the receiver operating characteristic curve; CTP: Child-Turcotte-Pugh; MELD: Model for end-stage liver disease; CAR: C-reactive protein to albumin ratio; COSSH-ACLF: Chinese Group on Study of Severe Hepatitis B-Acute-on-Chronic Liver Failure.