Prognostic value of dynamic changes in C-reactive protein to albumin ratio in patients with acute-on-chronic liver failure

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World Journal of Hepatology

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1948-5182

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Retrospective Cohort Study

World J Hepatol. Sep 27, 2025; 17(9): 110652
Published online Sep 27, 2025. doi: 10.4254/wjh.v17.i9.110652

Table 2 Predictive performance of inflammatory markers for mortality

Inflammatory marker	28-day mortality, AUC (95%CI)	90-day mortality, AUC (95%CI)	28-day, P value vs baseline CAR	90-day, P value vs baseline CAR
Baseline inflammatory markers
C-reactive protein	0.652 (0.560-0.744)^a	0.624 (0.534-0.714)^a	0.032^a	0.041^a
White blood cell count	0.635 (0.542-0.728)^a	0.617 (0.527-0.707)^a	0.025^a	0.035^a
Neutrophil-lymphocyte ratio	0.645 (0.552-0.738)^a	0.619 (0.529-0.709)^a	0.028^a	0.038^a
Baseline CAR	0.698 (0.610-0.786)	0.662 (0.575-0.749)	Reference	Reference
Dynamic changes in CAR
ΔCAR-4	0.706 (0.618-0.794)	0.687 (0.602-0.772)	0.068	0.072
ΔCAR-7	0.765 (0.684-0.846)	0.723 (0.641-0.805)	0.003	0.006
ΔCAR-14	0.712 (0.625-0.799)	0.695 (0.611-0.779)	0.056	0.065

^aP < 0.05 vs baseline C-reactive protein to albumin ratio.

AUC: Area under the receiver operating characteristic curve; CAR: C-reactive protein to albumin ratio.

Citation: Zhu ZY, Yan LJ. Prognostic value of dynamic changes in C-reactive protein to albumin ratio in patients with acute-on-chronic liver failure. World J Hepatol 2025; 17(9): 110652
URL: https://www.wjgnet.com/1948-5182/full/v17/i9/110652.htm
DOI: https://dx.doi.org/10.4254/wjh.v17.i9.110652

Zhu ZY, Yan LJ. Prognostic value of dynamic changes in C-reactive protein to albumin ratio in patients with acute-on-chronic liver failure. World J Hepatol 2025; 17(9): 110652 [PMID: 41024884 DOI: 10.4254/wjh.v17.i9.110652]

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