Stratification and selection of therapies to improve survival in severe alcoholic hepatitis

Table 5 Fecal microbiota transplantation in severe alcoholic hepatitis

Ref.	Study design and inclusion criteria	Exclusion criteria	Infection rate
Pande et al[26] 2022	RCT, Adults with SAH	Creatinine > 1.5, MELD > 35; mDF > 90, GI bleed within 1 months	18.2%
Sharma et al[28] 2022	Prospective cohort study. Adults with SAH	Other causes of liver disease, uncontrolled infections, uncontrolled upper gastrointestinal bleeding, grade 3 or 4 hepatic encephalopathy, more than two organ failures, malignancy, intestinal paralysis, or perforation	30%
Philips et al[27] 2022	Retrospective. Adults with Steroids ineligible SAH	Hemodialysis at admission, disseminated intravascular coagulation, multi-organ failure, uncontrolled sepsis on inotropes, and other liver disease etiologies were excluded, as was gastrointestinal bleeding within a month	NA

RCT: Randomized controlled trial; SAH: Severe alcoholic hepatitis; MELD: Model for end stage liver disease; mDF: Maddrey’s discriminant function.