©The Author(s) 2025.
World J Hepatol. Sep 27, 2025; 17(9): 107671
Published online Sep 27, 2025. doi: 10.4254/wjh.v17.i9.107671
Published online Sep 27, 2025. doi: 10.4254/wjh.v17.i9.107671
Figure 2 Glypican-3-mediated Wnt/β-catenin and YAP/TAZ signaling axes in hepatocellular carcinoma.
GPC3 acts as a central signaling molecule that regulates two key pathways in hepatocellular carcinoma. One is the canonical Wnt/β-catenin pathway, where activated β-catenin translocates to the nucleus and induces the expression of oncogenic genes. The other is the alternative Wnt–YAP/TAZ pathway, in which activated YAP/TAZ translocate to the nucleus and promote tumor progression through transcriptional regulation. GPC3: Glypican-3.
- Citation: Wu CS, Lee TY, Chao HW. Targeting glypican-3 as a new frontier in liver cancer therapy. World J Hepatol 2025; 17(9): 107671
- URL: https://www.wjgnet.com/1948-5182/full/v17/i9/107671.htm
- DOI: https://dx.doi.org/10.4254/wjh.v17.i9.107671