Assessment of liver stiffness measurement-related markers in predicting liver-related events in viral cirrhosis with clinically significant portal hypertension

Table 3 Prognostic performance of liver stiffness measurement and its composite markers for liver related events

Cohort	AUROC (95%CI)	Sensitivity	Specificity	PPV	NPV	C-index (95%CI)
Training cohort
LSM	0.683 (0.632-0.733)	0.57	0.73	0.65	0.66	0.683 (0.631-0.734)
LPR	0.780 (0.736-0.824)	0.7	0.73	0.69	0.73	0.780 (0.736-0.825)
LAR	0.727 (0.679-0.775)	0.57	0.8	0.71	0.68	0.727 (0.678-0.776)
Validation cohort
LSM	0.661 (0.581-0.740)	0.56	0.7	0.61	0.65	0.661 (0.580-0.742)
LPR	0.753 (0.682-0.824)	0.62	0.8	0.73	0.72	0.753 (0.681-0.825)
LAR	0.686 (0.608-0.765)	0.76	0.6	0.61	0.74	0.686 (0.607-0.766)

LSM: Liver stiffness measurement; LPR: Liver stiffness measurement-platelet ratio; LAR: Liver stiffness measurement-albumin ratio; AUROC: Area under the receiver operating characteristic; PPV: Positive predictive value; NPV: Negative predictive value.