Assessment of liver stiffness measurement-related markers in predicting liver-related events in viral cirrhosis with clinically significant portal hypertension

Table 2 Risk factors for liver related events in compensated viral cirrhosis patients with clinically significant portal hypertension

	Univariate analysis		Multivariate analysis of LSM model		Multivariate analysis of LPR model		Multivariate analysis of LAR model
	HR (95%CI)	P value	aHR (95%CI)	P value	aHR (95%CI)	P value	aHR (95%CI)	P value
LSM	1.03 (1.02-1.04)	< 0.001	1.03 (1.02-1.04)	< 0.001
LPR	2.79 (2.10-3.69)	< 0.001			2.30 (1.55-3.42)	< 0.001
LAR	2.32 (1.79-3.00)	< 0.001					2.37 (1.66-3.38)	< 0.001
Age	1.01 (1.00-1.03)	0.146
Gender	0.88 (0.67-1.15)	0.337
Spleen diameter	1.06 (1.01-1.11)	0.020	0.99 (0.93-1.04)	0.600	0.99 (0.93-1.03)	0.436	0.99 (0.94-1.05)	0.677
AST	1.00 (1.00-1.01)	0.330
ALT	1.00 (1.00-1.00)	0.388
TB	1.01 (1.01-1.02)	0.002	1.00 (1.00-1.01)	0.821	1.00 (0.99-1.01)	0.813	1.00 (0.99-1.01)	0.501
ALB	0.96 (0.94-0.97)	< 0.001	0.99 (0.96-1.02)	0.552	0.99 (0.96-1.01)	0.337	1.01 (0.98-1.04)	0.490
INR	5.18 (1.98-13.54)	0.004	1.96 (0.73-5.28)	0.183	2.48 (0.94-6.54)	0.066	2.43 (0.91-6.46)	0.076
NLR	1.12 (1.04-1.20)	0.002	1.09 (1.01-1.18)	0.029	1.09 (1.01-1.18)	0.022	1.10 (1.02-1.18)	0.018
Hb	0.99 (0.98-0.99)	< 0.001	0.99 (0.99-1.01)	0.083	1.00 (0.99-1.00)	0.167	0.99 (0.99-1.00)	0.143
PLT	0.99 (0.99-1.00)	< 0.001	0.99 (0.99-1.00)	< 0.001	1.00 (0.99-1.00)	0.556	0.99 (0.99-1.00)	0.001

HR: Hazard ratios; aHR: Adjusted hazard ratios; LSM: Liver stiffness measurement; LPR: LSM-platelet ratio; LAR: LSM-albumin ratio; AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; TB: Total bilirubin; ALB: Albumin; INR: International normalized ratio; NLR: Neutrophil-to-lymphocyte ratio; Hb: Hemoglobin; PLT: Platelets.