Assessment of liver stiffness measurement-related markers in predicting liver-related events in viral cirrhosis with clinically significant portal hypertension

doi:10.4254/wjh.v17.i8.109796

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World Journal of Hepatology

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1948-5182

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World J Hepatol. Aug 27, 2025; 17(8): 109796
Published online Aug 27, 2025. doi: 10.4254/wjh.v17.i8.109796

Table 1 Baseline characteristics of compensated viral cirrhosis patients with clinically significant portal hypertension, n (%)

	Overall cohort (n = 598)	Training cohort (n = 419)	Validation cohort (n = 179)	P value
Age, years	54 (51-58)	54 (51-58)	53 (51-58.5)	0.498
Sex, male/female (%male)	400 (66.9)	275 (65.6)	125 (69.8)	0.318
LREs	319 (53.3)	222 (53.0)	97 (54.2)	0.786
Decompensation	284 (46.5)	199 (47.5)	85 (47.5)
HCC	26 (4.3)	17 (4.1)	9 (5.0)
Liver-related death	9 (1.5)	6 (1.4)	3 (1.7)
Follow-up time, months	37 (21, 55)	37 (20.5, 56)	37 (22, 53.5)	0.913
Spleen diameter, cm	14.4 (12.7-16)	14.4 (12.7-16.1)	14.4 (12.8-16)	0.638
AST, U/L	33.5 (25.8-48.3)	34 (26.1-47.6)	32.5 (25.5-48.5)	0.402
ALT, U/L	27.1 (19.3-40)	27.6 (19.6-40.6)	26.2 (18.5-39.3)	0.434
TB, μmol/L	19.4 (14.4-28.9)	19.4 (14-29)	20.7 (14.9-28.7)	0.645
ALB, g/L	40.4 (35.7-45)	40.8 (36.1-45.3)	39.1 (35.1-44.3)	0.141
INR	1.17 (1.09-1.23)	1.17 (1.08-1.21)	1.18 (1.09-1.26)	0.196
NLR	1.91 (1.39-2.68)	1.89 (1.365-2.72)	1.95 (1.45-2.66)	0.683
Hb, g/L	138 (122-150)	137 (121-149.5)	140 (124-151)	0.101
PLT, 10⁹/L	78 (55-106)	76 (53.5-107.5)	82.4 (59-104)	0.240
LSM, kPa	26.6 (21.1-37.4)	26.3 (21.1-35.8)	27.4 (21.3-40.3)	0.246
LPR	0.37 (0.23-0.57)	0.37 (0.23-0.58)	0.35 (0.24-0.55)	0.830
LAR	0.68 (0.50, 1.02)	0.68 (0.5, 1.00)	0.68 (0.50, 1.05)	0.535

Medians (IQR) or counts (proportions). LREs: Liver related events; HCC: Hepatocellular carcinoma; AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; TB: Total bilirubin; ALB: Albumin; INR: International normalized ratio; NLR: Neutrophil-to-lymphocyte ratio; Hb: Hemoglobin; PLT: Platelets; LSM: Liver stiffness measurement; LPR: Liver stiffness measurement-platelet ratio; LAR: Liver stiffness measurement-albumin ratio.

Citation: Li YQ, Li YQ, Li JZ, Zhu BB, Lu Y, Feng Y, Wang XB. Assessment of liver stiffness measurement-related markers in predicting liver-related events in viral cirrhosis with clinically significant portal hypertension. World J Hepatol 2025; 17(8): 109796
URL: https://www.wjgnet.com/1948-5182/full/v17/i8/109796.htm
DOI: https://dx.doi.org/10.4254/wjh.v17.i8.109796