Hepatitis B virus rtCYE/rtCYEI mutations may contribute limited tenofovir resistance: Analysis of a large sample of Chinese patients

Figure 3 Three-dimensional structures of tenofovir disoproxil fumarate-binding domains of viral reverse-transcriptase. The effects of rtS106C+H126Y+D134E (rtCYE), and rtS106C+H126Y+D134E+L269I (rtCYEI) mutations on the binding ability of the hepatitis B virus (HBV) reverse transcriptase (RT) region to tenofovir disoproxil fumarate (TDF) were evaluated using a homology model constructed based on the crystal structure of human immunodeficiency virus RT. A: The binding domains of the wild-type with TDF; B: The rtCYE mutant with TDF; C: The rtCYEI mutant with TDF. TDF ligand and interacting residues are shown in stick format. rtCYE: rtS106C+H126Y+D134E; rtCYEI: rtS106C+H126Y+D134E+L269I.