Hepatitis B virus rtCYE/rtCYEI mutations may contribute limited tenofovir resistance: Analysis of a large sample of Chinese patients

doi:10.4254/wjh.v17.i8.107456

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Aug 27, 2025 (publication date) through Aug 27, 2025

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Hepatol. Aug 27, 2025; 17(8): 107456
Published online Aug 27, 2025. doi: 10.4254/wjh.v17.i8.107456

Table 2 Mutation patterns and clinical information of the patients with hepatitis B virus rtCYE/rtCYEI mutations

Patient	Date¹	GT	HBV DNA (log₁₀ IU/mL)	ALT (U/L)	HBeAg	NAs exposure (month)	Direct sequencing	Clonal sequencing (positive clone number/total tested clone number)
P1	2009.02	C	8.16	55	+	LAM (19)	rtS106C+H126Y+D134E	rtS106C+H126Y+D134E (18/20), rtS106C+H126Y+D134E+L80I+M204I (1/20), rtS106C+H126Y+D134E+L269I (1/20)
P2	2009.05	C	8.66	53	+	LdT (18)	rtS106C+H126Y+D134E+M204I	rtS106C+H126Y+D134E+M204I (19/20), rtS106C+H126Y+D134E+L80I+M204I (1/20)
P3	2012.04	C	8.10	589	+	LAM (33)	rtS106C+H126Y+D134E+L80I+L180M+M204I	rtS106C+H126Y+D134E+L80I+L180M+M204I (17/20), rtS106C+H126Y+D134E+L269I+L80I+L180M+M204I (3/20), rtS106C+H126Y+L80I+L180M+M204I (1/20)
P4	2013.06	C	6.77	375	+	ADV (55)	rtS106C+H126Y+D134E+L269I+A181V	rtS106C+H126Y+D134E+L269I+A181V (17/20), rtH126Y+L269I+A181V (3/20)
P5	2013.08	C	1.60	20	+	ADV (17)→ETV (15)	rtS106C+H126Y+D134E+L269I	rtS106C+H126Y+D134E+L269I (20/20)
P6	2013.08	C	5.52	20	-	LdT (16)	rtS106C+H126Y+D134E+L269I+M204I	rtS106C+H126Y+D134E+L269I (18/20), rtS106C+H126Y+D134E+L269I+M204I (2/20)
P7	2008.06	C	5.21	37	+	LAM (24)→ADV (18)	rtS106C+H126Y+D134E	rtH126Y (6/20), rtS106C+H126Y+D134E (14/20)
P8	2008.08	C	6.61	109	+	LdT (16)	rtS106C+H126Y+D134E+L80I+M204I	rtS106C+H126Y+D134E+L80I+M204I (19/20), rtS106C+H126Y+D134E+L269I+L80I+M204I (1/20)
P9	2009.04	C	3.77	87	-	ADV (32)	rtS106C+H126Y+D134E+L269I+N236T	rtS106C+H126Y+D134E+L269I (16/20), rtS106C+H126Y+D134E+L269I+N236T (4/20)
P10	2010.08	C	6.88	165	-	LAM (28)→ADV (12)	rtS106C+H126Y+D134E	rtS106C+H126Y+D134E (20/20)
P11	2012.09	C	4.50	35	-	LAM (38)	rtS106C+H126Y+D134E+L269I+M204I	rtS106C+H126Y+D134E+L269I+M204I (20/20)
P12	2014.06	C	4.18	75	-	LAM (36)→ADV (25)	rtS106C+H126Y+D134E+L269I	rtS106C+H126Y+D134E+L269I (16/20), rtS106C+H126Y+D134E (4/20)

¹Date for serum sampling for resistance testing.

HBV: Hepatitis B virus; ALT: Alanine aminotransferase; rtCYE, rtS106C+H126Y+D134E; rtCYEI, rtS106C+H126Y+D134E+L269I; GT: Genotype; NAs: Nucleoside/nucleotide analogues; LAM: Lamivudine; LdT: Telbivudine; ADV: Adefovir dipivoxil; ETV: Entecavir.

Citation: Si LL, Fan ZP, Liu WH, Chen RJ, Chen XY, Ji D, Li L, Chen C, Liao H, Wang J, Xu DP, Zhao J, Liu Y. Hepatitis B virus rtCYE/rtCYEI mutations may contribute limited tenofovir resistance: Analysis of a large sample of Chinese patients. World J Hepatol 2025; 17(8): 107456
URL: https://www.wjgnet.com/1948-5182/full/v17/i8/107456.htm
DOI: https://dx.doi.org/10.4254/wjh.v17.i8.107456