Evaluating serum extra spindle pole bodies-like 1 protein vs p53 antibody for hepatitis B virus-related hepatocellular carcinoma diagnosis

doi:10.4254/wjh.v17.i7.108850

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World Journal of Hepatology

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World J Hepatol. Jul 27, 2025; 17(7): 108850
Published online Jul 27, 2025. doi: 10.4254/wjh.v17.i7.108850

Table 3 Diagnostic reliability analysis of serum biomarkers for hepatitis B virus-related hepatocellular carcinoma, (n/N, 95%CI)

Group	Sensitivity%	Specificity%	Accuracy%	FNR%	FPR%	PPV %	NPV%
ESPL1	89.09^a^,^b (49/55, 0.809-0.971)	91.67 (55/60, 0.869-0.965)	90.43^a^,^b (104/115, 0.874-0.934)	10.91^a^,^b (6/55, 0.041-0.177)	8.33 (5/60, 0.040-0.126)	90.74 (49/54, 0.854-0.960)	90.16^a^,^b (55/61, 0.861-0.943)
p53 antibody	63.64 (35/55, 0.539-0.734)	90.0 (54/60, 0.854-0.946)	77.39 (89/115, 0.742-0.806)	36.36 (20/55, 0.264-0.464)	10.00 (6/60, 0.056-0.144)	85.37 (35/41, 0.758-0.950)	72.97 (54/74, 0.680-0.780)
AFP	47.27 (26/55, 0.373-0.573)	93.33 (56/60, 0.901-0.965)	71.30 (82/115, 0.684-0.742)	52.73 (29/55, 0.427-0.627)	6.67 (4/60, 0.034-0.133)	86.67 (26/30, 0.860-0.933)	65.89 (56/85, 0.658-0.889)

^aP < 0.05 vs p53 antibody.

^bP < 0.05 vs alpha-fetoprotein.

ESPL1: Extra spindle pole bodies-like 1; AFP: Alpha-fetoprotein; FNR: False negative rate; FPR: False positive rate; PPV: Positive predictive value; NPV: Negative predictive value.

Citation: Feng YF, Zhou HK, Hu BB, Wang H, Liang HK, Wei L, Li QM, Su TM, Yin QB, Su MH, Jiang JN. Evaluating serum extra spindle pole bodies-like 1 protein vs p53 antibody for hepatitis B virus-related hepatocellular carcinoma diagnosis. World J Hepatol 2025; 17(7): 108850
URL: https://www.wjgnet.com/1948-5182/full/v17/i7/108850.htm
DOI: https://dx.doi.org/10.4254/wjh.v17.i7.108850