Evaluating serum extra spindle pole bodies-like 1 protein vs p53 antibody for hepatitis B virus-related hepatocellular carcinoma diagnosis

doi:10.4254/wjh.v17.i7.108850

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Jul 27, 2025 (publication date) through Jul 28, 2025

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Hepatol. Jul 27, 2025; 17(7): 108850
Published online Jul 27, 2025. doi: 10.4254/wjh.v17.i7.108850

Table 2 Receiver operating characteristic curve analysis of serum biomarkers in the diagnosis of HBV-related hepatocellular carcinoma

Group	AUC	Youden's index	Cut-off value	95%CI	Z value	P value
ESPL1	0.917^a	0.808	216.82	0.850-0.960	13.827	< 0.001
p53 antibody	0.725	0.536	3.17	0.634-0.804	4.223	< 0.001
AFP	0.678	0.406	6.79	0.584-0.762	3.353	< 0.001

^aP < 0.05 vs p53 antibody.

ESPL1: Extra spindle pole bodies-like 1; AFP: Alpha-fetoprotein; AUC: Area under the curve.

Citation: Feng YF, Zhou HK, Hu BB, Wang H, Liang HK, Wei L, Li QM, Su TM, Yin QB, Su MH, Jiang JN. Evaluating serum extra spindle pole bodies-like 1 protein vs p53 antibody for hepatitis B virus-related hepatocellular carcinoma diagnosis. World J Hepatol 2025; 17(7): 108850
URL: https://www.wjgnet.com/1948-5182/full/v17/i7/108850.htm
DOI: https://dx.doi.org/10.4254/wjh.v17.i7.108850