Tumor necrosis factor alpha-induced protein 3: A key biomarker for response to ursodeoxycholic acid in primary biliary cholangitis

Figure 4 Risk factors and predictive performance of tumor necrosis factor alpha-induced protein 3 and fatigue for response to ursodeoxycholic acid in primary biliary cholangitis patients. A: Forest plot showed independent risk factors for response to ursodeoxycholic acid (UDCA) in primary biliary cholangitis patients. Fatigue (odds ratio = 5.572; 95%CI: 1.346-23.062, P = 0.018) and tumor necrosis factor alpha-induced protein 3 (TNFAIP3) expression (odds ratio = 0.851; 95%CI: 0.733-0.988, P = 0.035) were both identified as risk factors associated with poor response to UDCA. Variables with statistical significance are marked in orange, while non-significant variables are marked in blue; B: Receiver operating characteristic curve analysis of TNFAIP3 and fatigue for response to UDCA. The area under the curve values are 0691 for TNFAIP3, 0.704 for fatigue, and 0.848 for their combination. The orange, blue, and purple lines represent the combination, TNFAIP3 alone, and fatigue alone, respectively. OR: Odds ratio; ROC: Receiver operating characteristic; CI: Confidence interval; AUC: Area under the curve; TNFAIP3: Tumor necrosis factor alpha-induced protein 3; TBIL: Total bilirubin; ALP: Alkaline phosphatase; GGT: Gamma-glutamyl transpeptidase; ACA: Anti-centromere antibodies.