Tumor necrosis factor alpha-induced protein 3: A key biomarker for response to ursodeoxycholic acid in primary biliary cholangitis

Figure 2 Volcano plots and heatmaps of differentially expressed genes in primary biliary cholangitis datasets. A: Volcano plots of differentially expressed genes (DEGs) identified in GSE93170, GSE119600, and GSE159676 datasets. A total of 1335 upregulated and 1012 downregulated genes were identified in GSE93170, 1108 upregulated and 844 downregulated genes in GSE119600, and 375 upregulated and 247 downregulated genes in GSE159676 (adjusted P < 0.05; |log2 fold change| ≥ 0.2). Orange and purple points represent upregulated and downregulated genes, respectively; B: Heatmaps of the top 100 DEGs from each dataset, clustered by expression levels. Red and blue colors indicate higher and lower expression levels, respectively. PBC: Primary biliary cholangitis; HCs: Healthy controls.