Tumor necrosis factor alpha-induced protein 3: A key biomarker for response to ursodeoxycholic acid in primary biliary cholangitis

Table 2 Clinical and pathological features of primary biliary cholangitis patients with different tumor necrosis factor alpha-induced protein 3expressions, mean ± SD, n (%)

Characteristics	TNFAIP3-high (n = 28)	TNFAIP3-low (n = 43)	P value
Gender			0.515
Female	28 (100)	41 (95.3)
Male	0 (0)	2 (4.7)
Age (year)			0.004
Median (IQR)	46 (38-51)	53 (44-60)	-
Fatigue	11 (39.3)	10 (23.3)	0.148
Pruritus	3 (10.7)	8 (18.6)	0.508
PLT (109/L)	197.6 ± 12.8	214.2 ± 12.0	0.362
ALT (U/L)	78.3 ± 17.2	50.0 ± 7.9	0.100
AST (U/L)	69.3 ± 21.6	42.2 ± 6.4	0.161
ALP (U/L)	215.5 ± 35.4	131.8 ± 14.1	0.034
GGT (U/L)	193.7 ± 40.4	155.8 ± 42.8	0.545
TBIL (μmol/L)	41.9 ± 11.38	22.3 ± 3.2	0.107
TBA (μmol/L)	40.2 ± 14.7	19.8 ± 3.5	0.187
Albumin (g/L)	38.2 ± 1.0	40.0 ± 1.3	0.321
AMA	19 (67.9)	30 (69.8)	0.865
AMA-M2	19 (67.9)	28 (65.1)	0.811
Anti-sp100	7 (25.0)	10 (23.3)	0.866
Anti-gp210	11 (39.3)	15 (34.9)	0.707
ACA	3 (10.7)	11 (25.6)	0.143
IgM (g/L)	5.5 ± 1.8	3.1 ± 0.4	0.139
Splenomegaly	9 (32.1)	5 (11.6)	0.034
Osteoporosis	8 (28.6)	10 (23.3)	0.615
Liver fibrosis			0.698
I	19 (67.9)	26 (60.5)
II	6 (21.4)	15 (34.9)
III	3 (10.7)	2 (4.7)
IV	0 (0)	0 (0)
Ductopenia	10 (35.7)	9 (20.9)	0.169

IQR: Interquartile range; PLT: Platelets; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; ALP: Alkaline phosphatase; GGT: Gamma-glutamyl transpeptidase; TBA: Total bile acid; AMA: Anti-mitochondrial antibodies; ACA: Anti-centromere antibodies; IgM: Immunoglobulin M; TNFAIP3: Tumor necrosis factor alpha-induced protein 3.