Tumor necrosis factor alpha-induced protein 3: A key biomarker for response to ursodeoxycholic acid in primary biliary cholangitis

doi:10.4254/wjh.v17.i7.107666

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 17, Issue 7

This Article

Academic Content and Language Evaluation of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Supplementary Materials of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (130)

All Articles published online

The chart showing PDF series, HTML series, Figures (1-5) series, Tables (1-2) series.

Item

Count

PDF

HTML

Figures (1-5)

Tables (1-2)

Sum=98

Publishing Process of This Article

The chart showing Browse series, Download series.

Item

Count

Browse

Download

Sum=24

Jul 27, 2025 (publication date) through Jul 28, 2025

Times Cited of This Article

Times Cited (0)

Journal Information of This Article

Publication Name

World Journal of Hepatology

ISSN

1948-5182

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Basic Study

World J Hepatol. Jul 27, 2025; 17(7): 107666
Published online Jul 27, 2025. doi: 10.4254/wjh.v17.i7.107666

Table 1 Clinical, pathological, and tumor necrosis factor alpha-induced protein 3 expression characteristics of primary biliary cholangitis patients with different response to ursodeoxycholic acid, mean ± SD, n (%)

Characteristics	All patients (n = 71)	UDCA-responders (n = 46)	UDCA-non-responders (n = 25)	P value
Gender				1.000
Female	69 (97.2)	45 (97.8)	24 (96.0)
Male	2 (2.8)	1 (2.2)	1 (4.0)
Age (year)				0.479
Median (IQR)	51 (42-57)	51 (42-58)	48 (43-57)	-
Fatigue	21 (29.6)	7 (15.2)	14 (56.0)	0.001
Pruritus	11 (15.5)	6 (13.0)	5 (20.0)	0.439
PLT (10⁹/L)	207.7 ± 8.8	217.6 ± 11.8	189.4 ± 12.0	0.127
ALT (U/L)	61.1 ± 8.4	55.2 ± 11.0	72.1 ± 12.6	0.341
AST (U/L)	52.9 ± 9.4	48.6 ± 13.3	60.8 ± 10.9	0.541
ALP (U/L)	164.8 ± 16.9	124.0 ± 12.2	239.9 ± 38.7	0.008
GGT (U/L)	172.4 ± 30.7	109.4 ± 16.5	283.6 ± 76.5	0.035
TBIL (μmol/L)	30.0 ± 5.0	20.7 ± 3.7	47.1 ± 11.8	0.041
TBA (μmol/L)	27.9 ± 6.2	21.9 ± 5.2	38.8 ± 14.8	0.194
Albumin (g/L)	39.3 ± 0.9	40.0 ± 1.2	38.0 ± 1.1	0.258
AMA	49 (69.0)	33 (71.7)	16 (64.0)	0.501
AMA-M2	47 (66.2)	32 (69.6)	15 (60.0)	0.416
Anti-sp100	17 (23.9)	11 (23.9)	6 (24.0)	0.993
Anti-gp210	26 (36.6)	13 (28.3)	13 (52.0)	0.047
ACA	14 (19.7)	13 (28.3)	1 (4.0)	0.014
IgM (g/L)	4.1 ± 0.8	3.1 ± 0.4	5.8 ± 2.0	0.092
Splenomegaly	14 (19.7)	7 (15.2)	7 (28.0)	0.196
Osteoporosis	18 (25.4)	11 (23.9)	7 (28.0)	0.705
Liver Fibrosis				0.106
I	45 (63.4)	29 (63.0)	16 (64.0)
II	21 (29.6)	15 (32.6)	6 (24.0)
III	5 (7.0)	2 (4.3)	3 (12.0)
IV	0 (0)	0 (0)	0 (0)
Ductopenia	19 (26.8)	10 (21.7)	9 (36.0)	0.195
TNFAIP3 (IOD)	10.1 ± 0.5	9.0 ± 0.6	12.3 ± 1.0	0.003

IQR: Interquartile range; PLT: Platelets; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; ALP: Alkaline phosphatase; GGT: Gamma-glutamyl transpeptidase; TBIL: Total bilirubin; TBA: Total bile acid; AMA: Anti-mitochondrial antibodies; ACA: Anti-centromere antibodies; IgM: Immunoglobulin M; IOD: Integrated optical density; TNFAIP3: Tumor necrosis factor alpha-induced protein 3; UDCA: Ursodeoxycholic acid.

Citation: Zang B, Li JX, Liu QX, Yao Y, Li H, Wang Y, Wang JG, Yang YF, Liang RW, Xin XR, Liu B. Tumor necrosis factor alpha-induced protein 3: A key biomarker for response to ursodeoxycholic acid in primary biliary cholangitis. World J Hepatol 2025; 17(7): 107666
URL: https://www.wjgnet.com/1948-5182/full/v17/i7/107666.htm
DOI: https://dx.doi.org/10.4254/wjh.v17.i7.107666