Advancing therapeutic vaccines for chronic hepatitis B: Integrating reverse vaccinology and immunoinformatics

doi:10.4254/wjh.v17.i7.107620

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Hepatol. Jul 27, 2025; 17(7): 107620
Published online Jul 27, 2025. doi: 10.4254/wjh.v17.i7.107620

Table 2 Web servers available for epitope selection

Parameter	Web server	Accuracy (%)	Link	Ref.
Antigenicity	Vaxijen v.2.0	70-89	https://www.ddg-pharmfac.net/vaxijen/VaxiJen/VaxiJen.html	Doytchinova and Flower[121], 2007
	Antigenic	78.04-80.03	http://77.68.43.135:8080/Antigenic/	Rahman et al[122], 2019
	ANTIGENpro	76	http://scratch.proteomics.ics.uci.edu/	Magnan et al[123], 2010
Toxicity	ToxinPred3.0	93	https://webs.iiitd.edu.in/raghava/toxinpred3/prediction.php	Rathore et al[124], 2024
	ToxDL	83-90	http://www.csbio.sjtu.edu.cn/bioinf/ToxDL/	Pan et al[125], 2021
	ToxIBTL	96	http://server.wei-group.net/ToxIBTL	Wei et al[126], 2022
Immunogenicity	IEDB Immunogenicity	66	http://tools.iedb.org/immunogenicity/	Calis et al[127], 2013
	AbImmPred	72.73	https://www.genscript.com/tools/antibody-immunogenicity	Wang et al[128], 2024
	DeepImmuno	80-90	https://deepimmuno.herokuapp.com/	Li et al[129], 2021
Allergenicity	AllergenFP v.1.0	88	https://www.ddg-pharmfac.net/AllergenFP/index.html	Dimitrov et al[130], 2014
	AllerTOP v.2	85.3	https://www.ddg-pharmfac.net/AllerTOP/	Dimitrov et al[131], 2014
	AllerCatPro 2.0	84.7	https://allercatpro.bii.a-star.edu.sg/	Nguyen et al[132], 2022
Population coverage	IEDB Population Coverage	N/A	http://tools.iedb.org/population/	Bui et al[133], 2006
Autoimunity	miPepBase	N/A	http://proteininformatics.org/mkumar/mipepbase/index.html	Garg et al[134], 2017
Anti-inflammatory	AIPpred	73.4	http://211.239.150.230/AIPpred/AIPpredMethod.html	Manavalan et al[135], 2018
	PreAIP	76.7	http://kurata14.bio.kyutech.ac.jp/PreAIP/	Khatun et al[136], 2019
	PepNet	95	http://liulab.top/PepNet/server	Han et al[137], 2024
IFN-γ induction	IFNepitope	82.1	https://webs.iiitd.edu.in/raghava/ifnepitope/run_submit-old.php	Dhanda et al[138], 2013
IFN-γ induction	PIP-EL	74.8	http://www.thegleelab.org/PIP-EL/	Manavalan et al[139], 2018

N/A: Not applicable.

Citation: Naully PG, Tan MI, El Khobar KE, Sukowati CHC, Giri-Rachman EA. Advancing therapeutic vaccines for chronic hepatitis B: Integrating reverse vaccinology and immunoinformatics. World J Hepatol 2025; 17(7): 107620
URL: https://www.wjgnet.com/1948-5182/full/v17/i7/107620.htm
DOI: https://dx.doi.org/10.4254/wjh.v17.i7.107620