Role of mac-2 binding protein glycosylation isomer in predicting fibrosis in patients with metabolic dysfunction-associated steatotic liver disease

Table 2 Variables according to fibrosis stages stratified by magnetic resonance elastography, n (%)

Variables	No or mild fibrosis (group 1) [Median (IQR)]	Significant fibrosis (group 2) [Median (IQR)]	Cirrhosis (group 3) [Median (IQR)]	P value1
				Group 1 vs group 2	Group 2 vs group 3	Group 1 vs group 3	All
Age (years)	49 (40.75-56.00)	53 (42-61.75)	52 (43-62)	0.0604	0.9999	0.2393	0.06
Sex
Male	55 (61.1)	94 (57)	29 (67.4)	ND	ND	ND	ND
Female	35 (38.9)	71 (43)	14 (32.6)	ND	ND	ND	ND
Aspartate aminotransferase (U/L)	27 (21.84-36.25)	31 (22-45)	34.5 (25.25-53)	0.0724	0.0075	0.341	0.0062
Alanine aminotransferase (U/L)	31 (22.75-64.5)	45.5 (25-72.25)	47.5 (29-73.75)	0.1252	> 0.9999	0.2029	0.0741
Gamma glutamyl transferase (U/L)	58.5 (34-110.5)	70.5 (37.25-119)	84 (54-151)	0.6769	0.0987	0.0144	0.0187
Body mass index (kg/m2)	26.63 (24.4-28.9)	26.3 (24.4-28)	27 (24.8-31)	> 0.9999	0.1613	0.2832	0.1449
FibroScan (kPa)	6.3 (5.78-7.7)	8 (7.03-9.5)	11 (7.1-15.7)	< 0.0001	0.0018	< 0.0001	< 0.0001
Fibrosis-4 Index	0.76 (0.57-1.00)	0.95 (0.67-1.35)	1.18 (0.7-1.79)	0.0092	0.2237	0.0007	0.0004
Aspartate aminotransferase-to-platelet ratio index	0.26 (0.19-0.36)	0.32 (0.21-0.46)	0.33 (0.21-0.62)	0.023	> 0.9999	0.029	0.0073
Mac-2 binding protein glycosylation isomer (cut-off index)	0.57 (0.45-0.81)	0.68 (0.52-0.9)	0.78 (0.58-1.17)	0.038	0.39	0.005	0.0035
Hemoglobin A1c	5.78 (5.45-6.31)	6 (5.59-6.8)	5.92 (5.65-7.52)	0.0344	> 0.9999	0.1148	0.0241
Glucose (mmol/L)	5.85 (5.49-6.59)	6.42 (5.69-7.55)	6.42 (5.66-9.02)	0.0083	> 0.9999	0.0243	0.0041
Low density lipoprotein-cholesterol (mmol/L)	3.35 (2.61-4.19)	3.13 (2.45-4.1)	3.7 (2.62-4.59)	> 0.9999	0.2192	0.9231	0.1824
Triglycerides (mmol/L)	2.29 (1.62-3.22)	2.43 (1.75-3.68)	2.08 (1.73-3.28)	0.8688	> 0.9999	> 0.9999	0.4874
Total cholesterol (mmol/L)	5.3 (4.66-6.17)	5.24 (4.37-6.22)	5.57 (4.84-6.74)	> 0.9999	0.5871	> 0.9999	0.4242
Comorbidity
Hyperglycemia	20 (22.2)	71 (42.3)	22 (51.2)	ND	ND	ND	ND
Diabetes	15 (16.7)	52 (31)	16 (37.2)	ND	ND	ND	ND
Obesity	12 (13.3)	20 (11.9)	12 (27.9)	ND	ND	ND	ND

¹Dunn’s test was performed to compare individual groups in post-hoc analysis, P < 0.05.

ND: Not done; IQR: Interquartile range.