Deciphering the oncogenic role of Rac family small GTPase 3 in hepatocellular carcinoma through multiomics integration

Figure 6 E2F transcription factor 1 activates Rac family small GTPase 3 transcription by binding to the Rac family small GTPase 3 promoter region. A: Intersection Venn diagram of Rac family small GTPase 3 (RAC3)-associated upregulated genes and related transcription factors (TFs); B: Target gene RAC3 and its related TFs (it was sourced from the hTFtarget database); C and D: The binding site of E2F transcription factor 1 (E2F1) in the promoter region of RAC3 and the ten predominant binding sequences (they were obtained from JASPAR); E: E2F1 binding peak in the translation initiation region of RAC3 [it was derived from integrated analyses using Cistrome DB and Integrative Genomics Viewer (IGV v3.0.1)]. CEGs: Co-expressed genes; RAC3: Rac family small GTPase 3; RP: Regulatory potential.