Deciphering the oncogenic role of Rac family small GTPase 3 in hepatocellular carcinoma through multiomics integration

Table 2 Association between Rac family small GTPase 3 protein immunoreactivity and clinicopathological characteristics of hepatocellular carcinoma using an in-house developed immunohistochemistry assay

Clinicopathological parameters	Number	Rac family small GTPase 3 expression		χ2	P value
		High	Low
Age (years)
≥ 60	69	17	52	0.645	0.422
< 60	39	7	32
Gender
Male	93	62	31	2.239	0.135
Female	15	7	8
Pathologic grade
I-II	27	21	6	3.010	0.083
III-IV	81	48	33
Clinical stage
I-II	102	64	38	1.041	0.308
III-IV	6	5	1
Capsular invasion
Yes	76	53	23	3.802	0.051
No	32	16	16
Microvascular invasion
Yes	41	25	16	0.243	0.622
No	67	44	23
Satellite nodule
Yes	11	4	7	4.022	0.045
No	97	65	32
Liver cirrhosis
Yes	65	39	26	1.070	0.301
No	43	30	13
Alpha-fetoprotein
≥ 8.78 ng/mL	69	39	30	4.495	0.034
< 8.78 ng/mL	39	30	9
Hepatitis B virus
Yes	95	59	36	1.088	0.297
No	13	10	3