Machine learning to identify potential biomarkers for sarcopenia in liver cirrhosis

Figure 1 Analysis of serum metabolic profiling between sarcopenic and non-sarcopenic cirrhotic patients. A: Orthogonal partial least squares discriminant analysis (OPLS-DA) of metabolites in positive mode; B: Volcano plot of metabolites by univariate analysis in positive mode; C: OPLS-DA of metabolites in negative mode; D: Volcano plot of metabolites by univariate analysis in negative mode; E: Metabolite classes with significantly different concentrations between sarcopenic and non-sarcopenic cirrhotic patients; F: Enriched metabolic pathways of differential metabolites. VIP: Variable importance in the projection.